State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University, 510060, Guangzhou, China.
Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, 510060, Guangzhou, China.
Signal Transduct Target Ther. 2020 Oct 7;5(1):231. doi: 10.1038/s41392-020-00326-0.
Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms, and provides the reducing power for anabolic reactions and redox balance. NADPH homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells. The metabolic reprogramming of NADPH renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress. Modulating the unique NADPH homeostasis of cancer cells might be an effective strategy to eliminate these cells. In this review, we summarize the current existing literatures on NADPH homeostasis, including its biological functions, regulatory mechanisms and the corresponding therapeutic interventions in human cancers, providing insights into therapeutic implications of targeting NADPH metabolism and the associated mechanism for cancer therapy.
烟酰胺腺嘌呤二核苷酸磷酸（NADPH）是所有生物中必不可少的电子供体，为合成代谢反应和氧化还原平衡提供还原能力。NADPH 稳态由多种信号通路和几种代谢酶调节，这些代谢酶在癌细胞中发生适应性改变。NADPH 的代谢重编程使癌细胞对这种代谢网络的抗氧化能力高度依赖，并且更容易受到氧化应激的影响。调节癌细胞独特的 NADPH 稳态可能是消除这些细胞的有效策略。在这篇综述中，我们总结了 NADPH 稳态的现有文献，包括其生物学功能、调节机制以及在人类癌症中的相应治疗干预措施，为靶向 NADPH 代谢及其相关癌症治疗机制的治疗意义提供了深入了解。
