Auge B, Donnio P Y, Le Deaut P, Avril J L
Pathol Biol (Paris). 1987 May;35(5):673-5.
An IV vancomycin treatment induces a reduction of Gram positive cocci (Staphylococcus, Enterococcus) of the aerobic salivary and fecal flora. Some of these strains persisted during and after treatment, but remained susceptible to vancomycin. Others isolated Gram positive cocci were resistant to vancomycin before and after treatment. They were identified as Pediococcus sp., and Leuconostoc sp. There is a reduction of the number of Gram positive cocci, without increase of Gram negative rods, Lactobacillus, or Candida which are always resistant to vancomycin.
静脉注射万古霉素治疗可使需氧唾液和粪便菌群中的革兰氏阳性球菌(葡萄球菌、肠球菌)数量减少。其中一些菌株在治疗期间及之后持续存在,但仍对万古霉素敏感。其他分离出的革兰氏阳性球菌在治疗前后均对万古霉素耐药。它们被鉴定为片球菌属和明串珠菌属。革兰氏阳性球菌数量减少,而革兰氏阴性杆菌、乳酸杆菌或念珠菌(这些菌一直对万古霉素耐药)的数量并未增加。