迈向新冠病毒药物的许多小步骤。
Many small steps towards a COVID-19 drug.
机构信息
Frontier Medicines Corporation, 151 Oyster Point Blvd., 2nd Floor, South San Francisco, CA, 94080, USA.
出版信息
Nat Commun. 2020 Oct 7;11(1):5048. doi: 10.1038/s41467-020-18710-3.
Abstract
A large-scale screening campaign has yielded dozens of crystal structures of small molecule fragments that bind to the main protease of SARS-CoV-2. The global research community is encouraged to pursue these as drug discovery starting points for COVID-19.
摘要
一项大规模的筛选活动产生了数十个小分子片段与 SARS-CoV-2 主蛋白酶结合的晶体结构。全球研究界被鼓励将这些作为 COVID-19 的药物发现起点进行探索。
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