Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, People's Republic of China.
Department of Hyperbaric Medicine, 6th Medical Center of PLA General Hospital, Beijing, People's Republic of China.
Sci Rep. 2020 Oct 7;10(1):16697. doi: 10.1038/s41598-020-73104-1.
We aimed to compare the electrophysiology and magnetic resonance neurography (MRN) results of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) subtypes and to explore the progression from atypical CIDP to typical CIDP. We collected the medical records of 45 CIDP patients to analyse the rate of progression from atypical CIDP to typical CIDP subtypes. The cerebrospinal fluid (CSF) protein (p = 0.024) and overall disability sum score (ODSS) (p = 0.000) differed among patients with typical CIDP, distal acquired demyelinating symmetric neuropathy (DADS) and Lewis-Sumner syndrome (LSS). The compound motor action potential (CMAP) of typical CIDP was lower than that of the other subtypes (p = 0.016, p = 0.022 and p = 0.012). The cross-sectional area (CSA) of nerve roots in typical CIDP was significantly thicker than that of nerve roots in DADS and LSS. There were fewer DADS and LSS patients who progressed to typical CIDP than those who progressed to pure motor and pure sensory CIDP (p = 0.000), and the progression from pure motor to typical CIDP required a significantly longer time than the progression from pure sensory to typical CIDP (p = 0.007). Typical CIDP was more severe than the other subtypes not only in terms of clinical and electrophysiology factors but also in terms of MRN factors.
我们旨在比较慢性炎症性脱髓鞘性多发性神经病（CIDP）各亚型的电生理学和磁共振神经成像（MRN）结果，并探讨从非典型 CIDP 进展为典型 CIDP 的情况。我们收集了 45 例 CIDP 患者的病历，以分析从非典型 CIDP 进展为典型 CIDP 各亚型的比例。脑脊液（CSF）蛋白（p=0.024）和总体残疾评分（ODSS）（p=0.000）在典型 CIDP、远端获得性脱髓鞘对称性神经病（DADS）和 Lewis-Sumner 综合征（LSS）患者之间存在差异。典型 CIDP 的复合运动动作电位（CMAP）低于其他亚型（p=0.016、p=0.022 和 p=0.012）。典型 CIDP 的神经根横截面积（CSA）明显大于 DADS 和 LSS 的神经根 CSA。进展为典型 CIDP 的 DADS 和 LSS 患者比进展为单纯运动型和单纯感觉型 CIDP 的患者少（p=0.000），而且从单纯运动型进展为典型 CIDP 所需的时间明显长于从单纯感觉型进展为典型 CIDP 的时间（p=0.007）。典型 CIDP 不仅在临床和电生理因素方面，而且在 MRN 因素方面，均比其他亚型更为严重。
