Fesseha Haben, Mathewos Mesfin, Kidanemariam Friat
Wolaita Sodo University, School of Veterinary Medicine, Department of Veterinary Surgery and Diagnostic Imaging, P.O. Box 138, Wolaita Sodo, Ethiopia.
Wolaita Sodo University, School of Veterinary Medicine, Department of Veterinary Pathology, P.O. Box 138, Wolaita Sodo, Ethiopia.
Vet Med Int. 2020 Sep 24;2020:4868797. doi: 10.1155/2020/4868797. eCollection 2020.
Gastrointestinal helminth parasite infection is a major influencing factor against profitability of working equines all over the world.
A study was conducted from October 2016 to May 2017 in and around Hosaena to determine the efficacy of benzimidazole (BZ) and avermectin (AVM) chemical groups against strongyle nematodes in working donkeys.
A total of 230 donkeys from Hosaena, Soro, Anlemo, and Gombora were randomly allocated into 5 groups of 46 donkeys in each group. All groups, except group 1 (control), were treated with ivermectin 1%, ivertong 10%, fenbendazole, and Fenacure 750 mg, respectively. Fecal samples were collected perrectally before treatment (day 0) and after treatment (day 14), and an egg per gram (EPG) value of >200 was used as a cutoff for inclusion to assess the efficacy of anthelmintics.
Accordingly, the study revealed that AVM was effective against strongyle nematodes of donkeys with the mean fecal egg count reduction (FECR) of 100% in three study areas and 97.2% in one study area, respectively, whereas BZ resistance was suspected in the areas where the drug was tested, with the mean FECR of less than 94% in the three study areas. The study also revealed that 73% of the donkeys were affected with a severe degree of strongyle infection as determined by EPG, while 10.4% of donkeys were affected with a mild degree of infection.
The findings of the present study are expected to serve as baseline data for future investigations and control actions to design realistic control programs to minimize factors that favor emergence of anthelmintic resistance and improve the overall health of the donkeys. Thus, further detailed studies are needed to determine the factors that reduce anthelmintic efficacy and increase anthelmintic resistance in donkeys.
胃肠道蠕虫寄生虫感染是影响全球役用马盈利能力的主要因素。
2016年10月至2017年5月在霍塞纳及其周边地区开展了一项研究，以确定苯并咪唑（BZ）和阿维菌素（AVM）化学组对役用驴体内圆线虫的疗效。
从霍塞纳、索罗、安莱莫和贡博拉共收集230头驴，随机分为5组，每组46头。除第1组（对照组）外，其余各组分别用1%伊维菌素、10%伊维通、芬苯达唑和750毫克非班太尔进行治疗。在治疗前（第0天）和治疗后（第14天）经直肠采集粪便样本，每克粪便虫卵数（EPG）>200作为纳入标准来评估驱虫药的疗效。
相应地，研究表明，AVM对驴的圆线虫有效，在三个研究区域平均粪便虫卵计数减少率（FECR）分别为100%，在一个研究区域为97.2%，而在测试该药物的区域怀疑存在BZ耐药性，三个研究区域的平均FECR均低于94%。研究还表明，根据EPG测定，73%的驴受到严重程度的圆线虫感染，而10.4%的驴受到轻度感染。
本研究结果有望作为未来调查和控制行动的基线数据，以设计切实可行的控制方案，尽量减少有利于驱虫药耐药性出现的因素，并改善驴的整体健康状况。因此，需要进一步开展详细研究，以确定降低驴驱虫药疗效和增加驱虫药耐药性的因素。
