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2019年冠状病毒病在新生儿中的情况——已知与未知

Coronavirus Disease 2019 in Neonates - What Is Known and What Needs to Be Known.

作者信息

Nayak Manas, Panda Santosh, Pradhan Janaki Ballav, Mohakud Nirmal K

机构信息

Neonatology, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.

Pediatric Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.

出版信息

Cureus. 2020 Aug 31;12(8):e10171. doi: 10.7759/cureus.10171.

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first broke out in Wuhan, China, and subsequently spread worldwide affecting all ages including newborns. The cases of coronavirus disease 2019 (COVID-19) are very less in neonates and they recover well with supportive treatment. Though the vertical transmission of infection is scarcely found, to get rid of acquiring infection by horizontal transmission one should screen all pregnant women and ensure standard infection control measures and monitoring of newborns at risk of COVID-19. Neonates may present as a refusal to feed, feeding intolerance, fever, pneumonia, shortness of breath, and lethargic. Based on available evidence, antivirals like lopinavir, ritonavir, remdesivir specific medication like chloroquine/hydroxychloroquine, azithromycin, corticosteroids, and intravenous gamma globulin, are not recommended, so early detection and supportive treatment is needed for an optimal outcome.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)最初在中国武汉爆发,随后在全球范围内传播,影响包括新生儿在内的所有年龄段人群。2019冠状病毒病(COVID-19)在新生儿中的病例非常少,他们通过支持性治疗恢复良好。虽然几乎未发现感染的垂直传播,但为避免通过水平传播感染,应筛查所有孕妇,并确保标准的感染控制措施以及对有COVID-19感染风险的新生儿进行监测。新生儿可能表现为拒食、喂养不耐受、发热、肺炎、呼吸急促和嗜睡。根据现有证据,不推荐使用洛匹那韦、利托那韦、瑞德西韦等抗病毒药物,以及氯喹/羟氯喹、阿奇霉素、皮质类固醇和静脉注射丙种球蛋白等特定药物,因此需要早期检测和支持性治疗以获得最佳结果。

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