Department of Neurology, The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Centre, New York, NY, USA.
Department of Biomedical Engineering, Columbia University Medical Centre, New York, NY, USA.
J Geriatr Psychiatry Neurol. 2022 Jan;35(1):78-88. doi: 10.1177/0891988720964258. Epub 2020 Oct 8.
To understand the differential neuroanatomical substrates underlying apathy and depression in Frontotemporal dementia (FTD).
T1-MRIs and clinical data of patients with behavioral and aphasic variants of FTD were obtained from an open database. Cortical thickness was derived, its association with apathy severity and difference between the depressed and not depressed were examined with appropriate covariates.
Apathy severity was significantly associated with cortical thinning of the lateral parts of the right sided frontal, temporal and parietal lobes. The right sided orbitofrontal, parsorbitalis and rostral anterior cingulate cortex were thicker in depressed compared to patients not depressed.
Greater thickness of right sided ventromedial and inferior frontal cortex in depression compared to patients without depression suggests a possible requisite of gray matter in this particular area for the manifestation of depression in FTD. This study demonstrates a method for deriving neuroanatomical patterns across non-harmonized neuroimaging data in a neurodegenerative disease.
了解额颞叶痴呆（FTD）中淡漠和抑郁的神经解剖学差异基础。
从一个开放数据库中获取行为和失语型 FTD 患者的 T1-MRI 和临床数据。得出皮质厚度，并使用适当的协变量检查其与淡漠严重程度的相关性，以及抑郁与非抑郁患者之间的差异。
淡漠严重程度与右侧额、颞和顶叶外侧部分的皮质变薄显著相关。与非抑郁患者相比，抑郁患者右侧眶额、眶额下和额前扣带回皮质更厚。
与无抑郁患者相比，抑郁患者右侧腹内侧和下额皮质的厚度更大，这表明在 FTD 中，该特定区域的灰质可能是抑郁表现的必要条件。本研究展示了一种在神经退行性疾病中跨非协调神经影像学数据推导神经解剖模式的方法。
