Branco Thamyres, Oliveira Ligia Franco, Palinkas Marcelo, de Vasconcelos Paulo Batista, Oliveira Maria Carolina, Simões Belinda Pinto, Regalo Isabela Hallak, Siéssere Selma, Regalo Simone Cecilio Hallak
School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Faculty Anhanguera, Ribeirão Preto, São Paulo, Brazil.
Prague Med Rep. 2020;121(3):163-171. doi: 10.14712/23362936.2020.15.
Musculoskeletal system impairment is a major cause of functional alterations in subjects with systemic sclerosis. Autologous hematopoietic stem cell therapy (AHSCT) may have an important role in the treatment functional of systemic sclerosis patients. The aim of this pilot study was to assess whether AHSCT interferes with the electromyographic activity of the masseter and temporalis muscles of subjects with systemic sclerosis. Before transplantation, seven subjects with systemic sclerosis (mean age [± SD], 40.1 ± 9.6 years) underwent electromyographic analysis of the masseter and temporalis muscles in mandibular tasks at rest, right and left laterality, protrusion and maximum voluntary contraction. Two months after AHSCT, the subjects re-evaluated using the same methods. Data were analyzed using the repeated-measure test, with p<0.05 considered to be statistically significant. Two months after AHSCT, there was reduction in normalized electromyographic activity in the dental clenching in maximal voluntary contraction, with significant differences, for the left temporal muscle (p=0.04). AHSCT in subjects with systemic sclerosis promotes alterations in stomatognathic system function, especially those related to electromyographic activity of masticatory muscles.
肌肉骨骼系统损伤是系统性硬化症患者功能改变的主要原因。自体造血干细胞移植（AHSCT）可能在系统性硬化症患者的功能治疗中发挥重要作用。这项初步研究的目的是评估AHSCT是否会干扰系统性硬化症患者咬肌和颞肌的肌电活动。移植前，7名系统性硬化症患者（平均年龄[±标准差]，40.1±9.6岁）在休息、左右侧别、前伸和最大自主收缩的下颌任务中对咬肌和颞肌进行了肌电分析。AHSCT两个月后，使用相同方法对受试者进行重新评估。采用重复测量检验分析数据，p<0.05被认为具有统计学意义。AHSCT两个月后，最大自主收缩时紧咬牙齿的标准化肌电活动降低，左侧颞肌有显著差异（p=0.04）。系统性硬化症患者的AHSCT会促进口颌系统功能改变，尤其是与咀嚼肌肌电活动相关的功能改变。
