Department of Clinical Pharmacy, Faculty of Pharmacy, Marmara University, Istanbul, Turkey.
Acta Clin Belg. 2022 Apr;77(2):273-279. doi: 10.1080/17843286.2020.1829251. Epub 2020 Oct 8.
This study aimed to evaluate polypharmacy, potentially inappropriate prescribing (PIP) and medication complexity in Turkish older patients in the community pharmacy setting and to determine the factors associated with PIP.
This descriptive cross-sectional study was conducted in the community pharmacy setting in Istanbul. Older patients (≥65 years old) who chronically used at least one medication and visited the community pharmacy for any reason in the past 4 months were invited in this study. PIP was determined by using the Ghent Older People's Prescriptions Community Pharmacy Screening (GheOPS)-tool. The Turkish version of the Medication Regimen Complexity Index (MRCI) was used to determine medication complexity.
Polypharmacy (defined as the concurrent use of five or more medications) was found in 69.0% of 158 patients. A total of 398 PIPs were detected and 83.5% (n = 132) of older patients had at least one PIP. The median (IQR) MRCI score was 12.5 (7.0-19.6). The factors associated with having ≥2 PIP were advanced age (≥75 years old) (OR = 2.87, 95% CI 1.41-5.81; < 0.05), higher number of chronic diseases (when ≥3, OR = 8.51, 95% CI 3.66-19.76; < 0.05), receiving polypharmacy (OR = 8.92, 95% CI 4.09-19.46; < 0.05), and higher MRCI scores (when MRCI ≥12.5, OR = 4.40, 95% CI 2.22-8.71; < 0.05).
More than half of the Turkish older patients had polypharmacy and the rate of PIP was high. A higher number of PIP was associated with advanced age, higher number of chronic diseases, polypharmacy, and more complex medication regimens.
本研究旨在评估土耳其社区药房中老年患者的多种用药、潜在不适当用药（PIP）和药物复杂性，并确定与 PIP 相关的因素。
本研究为在伊斯坦布尔社区药房进行的描述性横断面研究。本研究邀请了过去 4 个月内因任何原因慢性使用至少一种药物并到社区药房就诊的≥65 岁老年患者。使用 Ghent Older People's Prescriptions Community Pharmacy Screening（GheOPS）工具确定 PIP。使用土耳其版药物治疗方案复杂性指数（MRCI）来确定药物复杂性。
在 158 名患者中，有 69.0%的患者存在多种用药（同时使用五种或更多药物）。共发现 398 例 PIP，83.5%（n=132）的老年患者至少有一种 PIP。MRCI 评分中位数（IQR）为 12.5（7.0-19.6）。与存在≥2 种 PIP 相关的因素包括高龄（≥75 岁）（OR=2.87，95%CI 1.41-5.81； <0.05）、患有更多种慢性病（当≥3 种时，OR=8.51，95%CI 3.66-19.76； <0.05）、接受多种药物治疗（OR=8.92，95%CI 4.09-19.46； <0.05）和更高的 MRCI 评分（当 MRCI≥12.5 时，OR=4.40，95%CI 2.22-8.71； <0.05）。
超过一半的土耳其老年患者存在多种用药，且 PIP 发生率较高。更多的 PIP 与高龄、更多种慢性病、多种药物治疗和更复杂的药物治疗方案有关。
