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土耳其社区药房中药物相关问题的识别与评估:一项描述性患病率研究。

Identification and evaluation of drug-related problems in community pharmacy in Turkey: a descriptive prevalence study.

作者信息

Bektay Muhammed Yunus, Ayhan Yunus Emre, Çakmak Merve, Mercumek Berre

机构信息

Department of Clinical Pharmacy, Faculty of Pharmacy, Istanbul University-Cerrahpasa, İstanbul, Türkiye.

Department of Clinical Pharmacy, Faculty of Pharmacy, Bezmialem Vakif University, İstanbul, Türkiye.

出版信息

BMC Prim Care. 2025 Aug 7;26(1):248. doi: 10.1186/s12875-025-02926-7.

Abstract

BACKGROUND

Community pharmacies (CPs) are key healthcare providers, playing a significant role in optimizing drug therapy and preventing drug-related problems (DRPs). This study aims to assess the prevalence, characteristics, and related factors of DRPs in Turkish patients in the community pharmacy setting.

METHODS

A cross-sectional, prospective study was conducted between December 2023 and December 2024 in a community pharmacy. A total of 100 patients were included after excluding those with incomplete data. DRPs were evaluated using the PCNE V9.1 classification system, while Medication Adherence Report Scale (MARS) and Medication Regimen Complexity Index (MRCI) were used to assess adherence and regimen complexity.

RESULTS

A total of 162 DRPs were identified, with an average of 1.6 DRPs per patient. DRPs were significantly associated with factors such as higher body mass index (p = 0.005), polypharmacy (p < 0.001), use of antidiabetic (p < 0.001) and antihypertensive medications (p = 0.005), and a higher number of comorbidities (p = 0.005). No significant relationship was observed between medication adherence and DRPs (p > 0.05).

DISCUSSION

This study is among the first in Türkiye to evaluate DRPs in chronic disease management within a community pharmacy setting. The findings highlight the importance of clinical pharmacists in identifying and managing DRPs and suggest the need for integrated interventions in healthcare teams to improve patient outcomes and medication safety.

摘要

背景

社区药房是关键的医疗服务提供者,在优化药物治疗和预防药物相关问题(DRP)方面发挥着重要作用。本研究旨在评估社区药房环境中土耳其患者DRP的患病率、特征及相关因素。

方法

2023年12月至2024年12月在一家社区药房进行了一项横断面前瞻性研究。排除数据不完整的患者后,共纳入100例患者。使用PCNE V9.1分类系统评估DRP,同时使用药物依从性报告量表(MARS)和药物治疗方案复杂性指数(MRCI)评估依从性和治疗方案复杂性。

结果

共识别出162个DRP,平均每位患者1.6个DRP。DRP与较高的体重指数(p = 0.005)、多种药物联合使用(p < 0.001)、使用抗糖尿病药物(p < 0.001)和抗高血压药物(p = 0.005)以及更多的合并症(p = 0.005)等因素显著相关。未观察到药物依从性与DRP之间存在显著关系(p > 0.05)。

讨论

本研究是土耳其首批在社区药房环境中评估慢性病管理中DRP的研究之一。研究结果突出了临床药师在识别和管理DRP方面的重要性,并表明医疗团队需要进行综合干预以改善患者结局和用药安全。

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