个体 PM 暴露与肺功能：来自一般人群的城市成年人系统性炎症和氧化损伤的潜在中介作用。
Personal PM exposure and lung function: Potential mediating role of systematic inflammation and oxidative damage in urban adults from the general population.
机构信息
Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
出版信息
Sci Total Environ. 2021 Feb 10;755(Pt 1):142522. doi: 10.1016/j.scitotenv.2020.142522. Epub 2020 Sep 24.
BACKGROUND
Short-term effects of fine particulate matter (PM) exposure on lung function have been reported. However, few studies have assessed PM exposure on the personal level, and the mechanism underlying the effects of PM exposure on lung function remains less clear.
OBJECTIVES
To evaluate the association between personal PM exposure and lung function alteration in general population and to explore the roles of systematic inflammation and oxidative damage in this association.
METHODS
A total of 7685 lung function tests were completed among 4697 urban adults in Wuhan, China. Plasma C-reactive protein (CRP), urinary 8-iso-prostaglandin-F (8-iso-PGF) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels were measured. Personal PM exposure levels were estimated using an estimation model from the actual measurements of individual PM levels in 191 participants. Mixed linear models were used to evaluate the association between personal PM exposure and lung function. Mediation analyses were conducted to investigate the roles of CRP, 8-iso-PGF and 8-OHdG in above associations.
RESULTS
After adjusting for confounders, each 10 μg/m increase in the previous-day personal PM exposure was associated with 2.94 mL, 2.02 mL and 16.14 mL/s decreases in forced vital capacity (FVC), forced expiration volume in 1 s (FEV) and peak expiratory flow, respectively. The associations were more obvious among never smokers compared with current smokers. Cumulative 7-day exposure to PM led to the strongest adverse effects on lung function. Among never smokers with high PM exposure levels, a positive relationship was observed between personal PM level and urinary 8-iso-PGF, and 8-iso-PGF meditated 4.69% and 12.30% of the association between the 7-day moving PM concentration and FVC and FEV, respectively. We did not observe a significant positive association between PM exposure and plasma CRP or urinary 8-OHdG.
CONCLUSION
Short-term personal exposure to PM is associated with reduced pulmonary ventilation function. Urinary 8-iso-PGF partly mediates these associations.
背景
已有研究报道短期细颗粒物（PM）暴露对肺功能的影响。然而，很少有研究在个体水平上评估 PM 暴露，PM 暴露对肺功能影响的机制仍不清楚。
目的
评估一般人群中个体 PM 暴露与肺功能改变的关系，并探讨系统性炎症和氧化损伤在此关联中的作用。
方法
在中国武汉，对 4697 名城市成年人进行了总共 7685 次肺功能测试。测量了血浆 C 反应蛋白（CRP）、尿液 8-异前列腺素 F（8-iso-PGF）和 8-羟基-2'-脱氧鸟苷（8-OHdG）水平。使用 191 名参与者个体 PM 水平实际测量的估计模型来估计个体 PM 暴露水平。使用混合线性模型评估个体 PM 暴露与肺功能之间的关系。进行中介分析以研究 CRP、8-iso-PGF 和 8-OHdG 在上述关联中的作用。
结果
在调整混杂因素后，前一天个体 PM 暴露每增加 10μg/m，用力肺活量（FVC）、1 秒用力呼气量（FEV）和呼气峰流速分别降低 2.94mL、2.02mL 和 16.14mL/s。与当前吸烟者相比，从不吸烟者的关联更为明显。7 天累积 PM 暴露对肺功能的不良影响最大。在高 PM 暴露水平的从不吸烟者中，个体 PM 水平与尿液 8-iso-PGF 之间存在正相关，尿液 8-iso-PGF 分别介导了 7 天移动 PM 浓度与 FVC 和 FEV 之间关联的 4.69%和 12.30%。我们没有观察到 PM 暴露与血浆 CRP 或尿液 8-OHdG 之间存在显著的正相关。
结论
短期个体 PM 暴露与肺通气功能下降有关。尿液 8-iso-PGF 部分介导了这些关联。
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