Department of Otorhinolaryngology, Dokuz Eylul University, School of Medicine, Izmir, Turkey.
Department of Pediatrics, Section of Immunology and Rheumatology, Dokuz Eylul University, School of Medicine, Izmir, Turkey.
Int J Pediatr Otorhinolaryngol. 2020 Dec;139:110417. doi: 10.1016/j.ijporl.2020.110417. Epub 2020 Sep 30.
To evaluate middle and inner ear function and hearing status of children with familial Mediterranean fever (FMF).
We assigned 56 patients with FMF to the study group and 52 healthy volunteers to the control group. The mean age of patients in the study and control groups were 10.10 ± 3.70 and 9.77 ± 3.74 years, respectively. Physical examination and hearing evaluation were performed in both groups. The audiological test battery included 226-Hz tympanometry, pure tone audiometric evaluation, acoustic stapedial reflex measurements, distortion product otoacoustic emission recording, and wide-band tympanometry assessment.
The groups were similar in age and sex ratio (p > 0.05 for both comparisons). Pure tone audiogram and distortion product otoacoustic emission results were also similar for both groups (p > 0.05). The ipsilateral acoustic stapedial reflex were present in both of the groups and all participants had Type A tympanogram. The contralateral acoustic stapedial reflex thresholds were significantly higher in the familial Mediterranean fever group (p < 0.05 for all comparisons). The ambient and peak pressure absorbance values of wide-band tympanometry were significantly lower at 2000 Hz and significantly higher at 4000 Hz in the familial Mediterranean fever group (p < 0.05 for both comparisons). The severity and duration of disease adversely affected the absorbance values of wide-band tympanometry at 2000 and 4000 Hz (p < 0.05).
To our knowledge, this is the first study to demonstrate the adverse subclinical effects of familial Mediterranean fever on the middle ear. We recommend that children diagnosed with FMF should be closely monitored for future clinical middle ear pathologies.
评估家族性地中海热（FMF）患儿的中耳和内耳功能及听力状况。
我们将 56 名 FMF 患者纳入研究组，52 名健康志愿者纳入对照组。研究组和对照组患者的平均年龄分别为 10.10±3.70 岁和 9.77±3.74 岁。两组均进行体格检查和听力评估。听力学测试包括 226-Hz 鼓室图、纯音听阈测试、声顺反射测量、畸变产物耳声发射记录和宽带鼓室图评估。
两组在年龄和性别比例方面无差异（p>0.05）。两组的纯音听阈和畸变产物耳声发射结果也相似（p>0.05）。两组的同侧声顺反射均存在，所有参与者的鼓室图均为 A 型。家族性地中海热组的对侧声顺反射阈值显著较高（所有比较的 p 值均<0.05）。宽带鼓室图的环境和峰值压力吸收率在 2000 Hz 时显著较低，在 4000 Hz 时显著较高（所有比较的 p 值均<0.05）。疾病的严重程度和持续时间对 2000 Hz 和 4000 Hz 宽带鼓室图的吸收率有不利影响（p 值均<0.05）。
据我们所知，这是首次研究表明家族性地中海热对中耳有亚临床不良影响。我们建议对诊断为 FMF 的儿童应密切监测未来的临床中耳病变。
