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以患者为中心的体重跟踪作为一种早期癌症检测策略。

Patient-centered Weight Tracking as an Early Cancer Detection Strategy.

作者信息

Hue Jonathan J, Markt Sarah C, Rao Goutham, Winter Jordan M

机构信息

Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, OH, USA.

Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, OH, USA.

出版信息

J Cancer Prev. 2020 Sep 30;25(3):181-188. doi: 10.15430/JCP.2020.25.3.181.

Abstract

Early detection is a valued strategy to decrease cancer mortality rates; however, new strategies are needed. Unintentional weight loss (UWL) is experienced by patients across the cancer spectrum, but often goes unnoticed. Patient-centered weight tracking may be a useful early detection marker. Fifty patients were enrolled in a prospective patient-centered weight tracking trial. Patients received a scale and monetary compensation to participate. A reminder to measure and record weight was texted to participants for 26 consecutive weeks. Most patients were black (86.0%) and female (68.0%). The median age was 47 years (range: 22-84 years). Many participants had Medicaid (42.0%) and the median household income by home zip code was $31,046. After 26 weeks, 90% of patients had recorded at least one weight. Among all patients, 73.7% of all possible weights were recorded and the median response rate per patient was 92.3% (24 of 26 weights). There was no difference in the response rates during the first and second halves of the study (77.7% vs. 69.7%, = 0.53). The range of weight change over the study period was 16.1% loss to 25.0% gain, with 56% of patients maintaining stable weight. Seven patients (14.0%) lost more than 5% weight and 11 patients (22.0%) gained over 5%. Of the seven patients with weight loss, two (4.0% of the cohort) were determined to have UWL. Patient-centered weight tracking is feasible and inexpensive, and has potential as an early detector of UWL. Further studies are needed to apply this strategy to detect underlying malignancies.

摘要

早期检测是降低癌症死亡率的一项重要策略;然而,仍需要新的策略。癌症患者普遍存在非故意体重减轻(UWL)的情况,但往往未被注意到。以患者为中心的体重追踪可能是一个有用的早期检测指标。五十名患者参与了一项以患者为中心的前瞻性体重追踪试验。患者因参与试验获得了一台秤和金钱补偿。连续26周向参与者发送测量和记录体重的提醒短信。大多数患者为黑人(86.0%)且为女性(68.0%)。中位年龄为47岁(范围:22 - 84岁)。许多参与者有医疗补助(42.0%),按家庭邮政编码计算的家庭收入中位数为31,046美元。26周后,90%的患者记录了至少一次体重。在所有患者中,记录了所有可能体重的73.7%,每位患者的中位回复率为92.3%(26次体重记录中的24次)。研究前半段和后半段的回复率没有差异(77.7%对69.7%,P = 0.53)。研究期间体重变化范围为减轻16.1%至增加25.0%,56%的患者体重保持稳定。七名患者(14.0%)体重减轻超过5%,11名患者(22.0%)体重增加超过5%。在体重减轻的七名患者中,两名(占队列的4.0%)被确定存在UWL。以患者为中心的体重追踪是可行且廉价的,并且有作为UWL早期检测手段的潜力。需要进一步研究以应用该策略来检测潜在的恶性肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d1c/7523038/b2b4ae47a4ae/JCP-25-181-f1.jpg

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