Hue Jonathan J, Markt Sarah C, Rao Goutham, Winter Jordan M
Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, OH, USA.
Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, OH, USA.
J Cancer Prev. 2020 Sep 30;25(3):181-188. doi: 10.15430/JCP.2020.25.3.181.
Early detection is a valued strategy to decrease cancer mortality rates; however, new strategies are needed. Unintentional weight loss (UWL) is experienced by patients across the cancer spectrum, but often goes unnoticed. Patient-centered weight tracking may be a useful early detection marker. Fifty patients were enrolled in a prospective patient-centered weight tracking trial. Patients received a scale and monetary compensation to participate. A reminder to measure and record weight was texted to participants for 26 consecutive weeks. Most patients were black (86.0%) and female (68.0%). The median age was 47 years (range: 22-84 years). Many participants had Medicaid (42.0%) and the median household income by home zip code was $31,046. After 26 weeks, 90% of patients had recorded at least one weight. Among all patients, 73.7% of all possible weights were recorded and the median response rate per patient was 92.3% (24 of 26 weights). There was no difference in the response rates during the first and second halves of the study (77.7% vs. 69.7%, = 0.53). The range of weight change over the study period was 16.1% loss to 25.0% gain, with 56% of patients maintaining stable weight. Seven patients (14.0%) lost more than 5% weight and 11 patients (22.0%) gained over 5%. Of the seven patients with weight loss, two (4.0% of the cohort) were determined to have UWL. Patient-centered weight tracking is feasible and inexpensive, and has potential as an early detector of UWL. Further studies are needed to apply this strategy to detect underlying malignancies.
早期检测是降低癌症死亡率的一项重要策略;然而,仍需要新的策略。癌症患者普遍存在非故意体重减轻(UWL)的情况,但往往未被注意到。以患者为中心的体重追踪可能是一个有用的早期检测指标。五十名患者参与了一项以患者为中心的前瞻性体重追踪试验。患者因参与试验获得了一台秤和金钱补偿。连续26周向参与者发送测量和记录体重的提醒短信。大多数患者为黑人(86.0%)且为女性(68.0%)。中位年龄为47岁(范围:22 - 84岁)。许多参与者有医疗补助(42.0%),按家庭邮政编码计算的家庭收入中位数为31,046美元。26周后,90%的患者记录了至少一次体重。在所有患者中,记录了所有可能体重的73.7%,每位患者的中位回复率为92.3%(26次体重记录中的24次)。研究前半段和后半段的回复率没有差异(77.7%对69.7%,P = 0.53)。研究期间体重变化范围为减轻16.1%至增加25.0%,56%的患者体重保持稳定。七名患者(14.0%)体重减轻超过5%,11名患者(22.0%)体重增加超过5%。在体重减轻的七名患者中,两名(占队列的4.0%)被确定存在UWL。以患者为中心的体重追踪是可行且廉价的,并且有作为UWL早期检测手段的潜力。需要进一步研究以应用该策略来检测潜在的恶性肿瘤。