脑损伤与阿尔茨海默病关联的最新进展。
Updates on the association of brain injury and Alzheimer's disease.
作者信息
Klomparens Kara, Ding Yuchuan
机构信息
Department of Neurosurgery, School of Medicine, Wayne State University, Detroit, MI, USA.
John D. Dingell VA Medical Center, Detroit, MI, USA.
出版信息
Brain Circ. 2020 Jun 26;6(2):65-69. doi: 10.4103/bc.bc_18_20. eCollection 2020 Apr-Jun.
Abstract
The purpose of this minireview is to outline the updates made on the association of Alzheimer's disease (AD) and brain injury. A review of the literature on this subject was conducted that included various aspects such as age of onset, severity of head trauma, and genetic influences. The results of this mini-review were that consistent associations of AD risk are seen when the severity of head trauma increases, the lag time decreases and when genetic links are present. Brain injury and AD have a complicated relationship that requires further studies to be fully understood.
摘要
本综述的目的是概述阿尔茨海默病（AD）与脑损伤之间关系的最新进展。对该主题的文献进行了综述，涵盖了发病年龄、头部创伤严重程度和遗传影响等各个方面。本综述的结果是，当头部创伤严重程度增加、延迟时间缩短以及存在遗传联系时，可观察到AD风险的一致关联。脑损伤与AD之间存在复杂的关系，需要进一步研究才能充分理解。
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本文引用的文献
1
Head or brain injuries and Alzheimer's disease: A nested case-control register study.头部或脑部损伤与阿尔茨海默病：巢式病例对照登记研究。
Alzheimers Dement. 2017 Dec;13(12):1371-1379. doi: 10.1016/j.jalz.2017.04.010. Epub 2017 Jun 7.
2
Traumatic brain injury history is associated with earlier age of onset of Alzheimer disease.创伤性脑损伤病史与阿尔茨海默病的发病年龄较早有关。
Clin Neuropsychol. 2017 Jan;31(1):85-98. doi: 10.1080/13854046.2016.1257069. Epub 2016 Nov 18.
3
Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings.创伤性脑损伤与老年神经退行性疾病和神经病理学发现的关联。
JAMA Neurol. 2016 Sep 1;73(9):1062-9. doi: 10.1001/jamaneurol.2016.1948.
4
Traumatic brain injury accelerates amyloid-β deposition and impairs spatial learning in the triple-transgenic mouse model of Alzheimer's disease.创伤性脑损伤会加速阿尔茨海默病三联转基因小鼠模型中β淀粉样蛋白的沉积，并损害其空间学习能力。
Neurosci Lett. 2016 Aug 26;629:62-67. doi: 10.1016/j.neulet.2016.06.066. Epub 2016 Jun 29.
5
Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort.在一个阿尔茨海默病中心队列中，自我报告的头部损伤与晚年功能障碍及阿尔茨海默病病理的风险
Dement Geriatr Cogn Disord. 2014;37(5-6):294-306. doi: 10.1159/000355478. Epub 2013 Dec 31.
6
Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study.基于人群的研究中头部创伤与淀粉样蛋白和神经退行性变的体内测量。
Neurology. 2014 Jan 7;82(1):70-6. doi: 10.1212/01.wnl.0000438229.56094.54. Epub 2013 Dec 26.
7
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J Neurosurg. 2009 Jun;110(6):1227-37. doi: 10.3171/2008.9.JNS08584.
8
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J Neurotrauma. 2008 Apr;25(4):279-90. doi: 10.1089/neu.2007.0489.
9
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Exp Neurol. 2007 Dec;208(2):185-92. doi: 10.1016/j.expneurol.2007.06.018. Epub 2007 Jul 10.
10
Risk factors for Alzheimer's disease in Russia: a case-control study.
Eur J Neurol. 2006 Sep;13(9):990-5. doi: 10.1111/j.1468-1331.2006.01391.x.
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