Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, 232890Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, New York, NY, USA.
5925Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J Intensive Care Med. 2021 Apr;36(4):494-499. doi: 10.1177/0885066620965163. Epub 2020 Oct 9.
COVID-19 has been associated with a dysregulated inflammatory response. Patients who have received solid-organ transplants are more susceptible to infections in general due to the use of immunosuppressants. We investigated factors associated with mechanical ventilation and outcomes in solid-organ transplant recipients with COVID-19.
We conducted a retrospective cohort study of all solid-organ transplant recipients admitted with a diagnosis of COVID-19 in our 23-hospital health system over a 1-month period. Descriptive statistics were used to describe hospital course and laboratory results and bivariate comparisons were performed on variables to determine differences.
Twenty-two patients with solid-organ transplants and COVID-19 were identified. Eight patients were admitted to the ICU, of which 7 were intubated. Admission values of CRP (p = 0.045) and N/L ratio (p = 0.047) were associated with the need for mechanical ventilation. Seven patients (32%) died during admission, including 86% (n = 6) of patients who received mechanical ventilation.
In solid-organ transplant recipients with COVID-19, initial CRP and N/L ratio were associated with need for mechanical ventilation.
COVID-19 与失调的炎症反应有关。由于使用免疫抑制剂，接受过实体器官移植的患者通常更容易受到感染。我们研究了与 COVID-19 实体器官移植受者机械通气和结局相关的因素。
我们对在我们的 23 家医院医疗系统中因 COVID-19 住院的所有实体器官移植受者进行了回顾性队列研究，为期 1 个月。使用描述性统计来描述住院过程和实验室结果，并对变量进行双变量比较以确定差异。
确定了 22 例患有 COVID-19 的实体器官移植受者。8 例患者入住 ICU，其中 7 例插管。入院时 CRP（p = 0.045）和 N/L 比值（p = 0.047）与机械通气的需要相关。7 名患者（32%）在住院期间死亡，其中接受机械通气的患者占 86%（n = 6）。
在患有 COVID-19 的实体器官移植受者中，初始 CRP 和 N/L 比值与机械通气的需要相关。
