用于准确检测严重急性呼吸综合征冠状病毒2 T细胞反应的干扰素-γ释放试验
Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response.
作者信息
Murugesan Kanagavel, Jagannathan Prasanna, Pham Tho D, Pandey Suchitra, Bonilla Hector F, Jacobson Karen, Parsonnet Julie, Andrews Jason R, Weiskopf Daniela, Sette Alessandro, Pinsky Benjamin A, Singh Upinder, Banaei Niaz
机构信息
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
出版信息
Clin Infect Dis. 2021 Nov 2;73(9):e3130-e3132. doi: 10.1093/cid/ciaa1537.
We investigated feasibility and accuracy of an interferon-γ release assay (IGRA) for detection of T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whole blood IGRA accurately distinguished between convalescent and uninfected healthy blood donors with a predominantly CD4+ T-cell response. SARS-CoV-2 IGRA may serve as a useful diagnostic tool in managing the coronavirus disease 2019 pandemic.
我们研究了一种用于检测针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的T细胞反应的干扰素-γ释放试验（IGRA）的可行性和准确性。全血IGRA能够准确区分康复期和未感染的健康献血者，主要表现为CD4+ T细胞反应。SARS-CoV-2 IGRA可能作为管理2019冠状病毒病大流行的一种有用诊断工具。
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