CAS Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
CAS Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100039, China; College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Biosens Bioelectron. 2020 Dec 15;170:112671. doi: 10.1016/j.bios.2020.112671. Epub 2020 Oct 4.
Acid phosphatase (ACP) is a lysosomal enzyme widely found in animals and plants. Particularly, abnormal ACP levels are often closely related to many diseases of the individual and are therefore widely used as biomarkers in clinical diagnosis. With the rapid development of precision medicine, the improvement or enhancement of the selectivity, sensitivity and broad target sample types of ACP biosensors based on the established methods has become an emerging demand for the treatment of diseases related to ACP levels. Therefore, a large number of ACP detection strategies have been used to improve these problems. In this review, the types and advantages/disadvantages of ACP detection methods were summarized and compared. According to the previous reports, the prospects and development trends of ACP detection were discussed. It was expected to provide some insights and inspiration for future research work.
酸性磷酸酶（ACP）是一种广泛存在于动物和植物中的溶酶体酶。特别是，异常的 ACP 水平通常与个体的许多疾病密切相关，因此被广泛用作临床诊断中的生物标志物。随着精准医学的快速发展，基于已建立方法的 ACP 生物传感器的选择性、灵敏度和广泛的目标样本类型的改进或增强已成为治疗与 ACP 水平相关疾病的新兴需求。因此，大量的 ACP 检测策略被用于解决这些问题。在这篇综述中，总结和比较了 ACP 检测方法的类型和优缺点。根据以往的报道，讨论了 ACP 检测的前景和发展趋势。希望为未来的研究工作提供一些见解和启示。
