Batzofin J H
Urol Clin North Am. 1987 Aug;14(3):609-18.
At present, laboratory methods that can successfully differentiate X- from Y-bearing sperm do exist; namely, staining with quinacrine mustard and DNA flow cytometry. However, methods that can successfully and reproducibly separate X- from Y-bearing sperm with resultant functionally intact sperm have yet to be developed. The area of sex selection is under intensive investigation, and a reliable method of separation will undoubtedly become available in the near future. To the extent that these techniques would be used to help couples avoid sex-linked genetic diseases, preimplantation gender selection is ethically justifiable. Social and ethical factors are important considerations in justifying other applications of these techniques.
目前，确实存在能够成功区分携带X染色体和携带Y染色体精子的实验室方法；即使用喹吖因氮芥染色和DNA流式细胞术。然而，能够成功且可重复地分离携带X染色体和携带Y染色体精子并使所得精子功能完整的方法尚未开发出来。性别选择领域正在进行深入研究，可靠的分离方法无疑将在不久的将来问世。就这些技术将被用于帮助夫妇避免性连锁遗传病而言，植入前性别选择在伦理上是合理的。在证明这些技术的其他应用合理时，社会和伦理因素是重要的考虑因素。
