University of Rochester School of Medicine and Dentistry, Rochester, New York.
Yale School of Public Health, New Haven, Connecticut.
Fertil Steril. 2020 Nov;114(5):1032-1039. doi: 10.1016/j.fertnstert.2020.06.002. Epub 2020 Oct 6.
To determine if short-term weight change among women with unexplained infertility (UI) and polycystic ovary syndrome (PCOS) undergoing ovulation induction is associated with live birth.
Secondary analysis of randomized trials.
Multicenter fertility trial sites.
PATIENT(S): A total of 900 women with UI and 750 women with PCOS.
MAIN OUTCOME MEASURE(S): Live birth.
INTERVENTION(S): Weight assessment at enrollment and start of up to 4-5 cycles of clomiphene, letrozole, or gonadotropins and intrauterine insemination for women with UI and clomiphene or letrozole with regular intercourse for women with PCOS.
RESULT(S): Weight data were available for 856 women with UI and 697 women with PCOS. Mean weight change was -0.2 ± 0.3 kg among women with UI and +2.2 ± 0.2 kg among women with PCOS and did not differ based on treatment allocation. There were 115 women with PCOS (16.4%) who gained ≥3 kg. Increased body mass index and three or more cycles were associated with weight gain in women with PCOS. There was no difference in live birth rate among women with PCOS and ≥3 kg weight gain and women with PCOS who did not gain weight.
CONCLUSION(S): Women with PCOS gained an average of 2.2 kg regardless of the medication received, whereas women with UI experienced no short-term weight change during ovulation induction. Weight gain in women with PCOS was not associated with live birth rate.
确定不明原因不孕（UI）和多囊卵巢综合征（PCOS）女性在接受促排卵治疗期间短期体重变化是否与活产有关。
随机试验的二次分析。
多中心生育试验点。
共 900 名 UI 患者和 750 名 PCOS 患者。
活产。
UI 患者在入组时和最多 4-5 个氯米芬、来曲唑或促性腺激素周期及宫腔内人工授精开始时进行体重评估，PCOS 患者进行氯米芬或来曲唑治疗并进行常规性交。
UI 患者体重数据可用于 856 例，PCOS 患者 697 例。UI 患者体重平均变化为-0.2 ± 0.3 公斤，PCOS 患者体重增加 2.2 ± 0.2 公斤，与治疗分配无关。有 115 名 PCOS 患者（16.4%）体重增加≥3 公斤。体重指数增加和三个或更多周期与 PCOS 患者的体重增加有关。体重增加≥3 公斤的 PCOS 患者与未增重的 PCOS 患者的活产率无差异。
无论接受何种药物治疗，PCOS 患者的体重平均增加 2.2 公斤，而 UI 患者在促排卵治疗期间体重没有短期变化。PCOS 患者的体重增加与活产率无关。
