Dermatology Unit "Daniele Innocenzi", Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Terracina, Italy.
Dermatol Ther. 2020 Nov;33(6):e14392. doi: 10.1111/dth.14392. Epub 2020 Nov 2.
Acne is a chronic inflammatory relapsing disease that affect predominantly adolescents, with scarring as a frequent sequele. Early and appropriate therapy allows better management of the disease, longer remission, scars risk reduction, and improvement of quality of life. According to therapeutic algorithm, systemic isotretinoin can be used in severe acne and also in moderate forms resistant to other systemic treatments. The aims of this real-life observational study were to determine and compare the effectiveness of isotretinoin evaluated by Global Acne Grading System and Acne Quality of Life in moderate and in severe acne, correlation between efficacy and cumulative dose of isotretinoin, tolerability, and recurrence rate. Moreover, the differences in efficacy and tolerability between male and female patients were compared. The treatment with systemic isotretinoin led to an improvement in acne severity and quality of life in all observed subjects.
痤疮是一种慢性炎症性复发性疾病，主要影响青少年，常伴有瘢痕形成。早期和适当的治疗可以更好地控制疾病，延长缓解期，降低疤痕风险，提高生活质量。根据治疗方案，异维 A 酸可用于重度痤疮，也可用于对其他全身治疗有抵抗的中度痤疮。本真实观察性研究的目的是确定并比较中重度痤疮患者应用全球痤疮分级系统和痤疮生活质量评估异维 A 酸的疗效，评估疗效与异维 A 酸累积剂量之间的相关性，评估其耐受性和复发率。此外，还比较了男性和女性患者之间疗效和耐受性的差异。全身应用异维 A 酸治疗可改善所有观察对象的痤疮严重程度和生活质量。
