Department of Microbiology and Immunology, University of Illinois College of Medicine Chicago, Chicago, IL, USA.
Clinic and Research Center of Tuberculosis, Shanghai Key Laboratory of Tuberculosis, Tongji University Shanghai Pulmonary Hospital, Shanghai, China.
Immunol Rev. 2020 Nov;298(1):254-263. doi: 10.1111/imr.12927. Epub 2020 Oct 10.
Unique Vγ2Vδ2 (Vγ9Vδ2) T cells existing only in human and non-human primates, account for the majority of circulating γδ T cells in human adults. Vγ2Vδ2 T cells are the sole γδ T-cell subpopulation capable of recognizing the microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by selected pathogens during infections. Recent seminal studies in non-human primate models have demonstrated that the unique HMBPP-specific Vγ2Vδ2 T cells are fast-acting, multi-functional, and protective during infections. This article reviews the recent seminal observations of Vγ2Vδ2 T cells in protective mechanisms against tuberculosis and other infections.
仅存在于人类和非人类灵长类动物中的独特 Vγ2Vδ2（Vγ9Vδ2）T 细胞，占成年人类循环 γδ T 细胞的大多数。Vγ2Vδ2 T 细胞是唯一能够识别感染期间某些病原体产生的微生物（E）-4-羟基-3-甲基-2-丁烯基焦磷酸（HMBPP）的 γδ T 细胞亚群。最近在非人类灵长类动物模型中的重要研究表明，独特的 HMBPP 特异性 Vγ2Vδ2 T 细胞在感染期间具有快速作用、多功能和保护作用。本文综述了最近关于 Vγ2Vδ2 T 细胞在抗结核和其他感染的保护机制中的重要观察结果。
