Kitano N, Taminato T, Seno M, Miyamoto Y, Seino Y, Matsukura S, Imura H
Acta Diabetol Lat. 1987 Jan-Mar;24(1):9-15. doi: 10.1007/BF02732048.
Insulin-dependent diabetes mellitus is frequently associated with organ-specific autoimmune diseases and/or high titers of organ-specific autoantibodies. The effects of thyroid autoantibodies on islet-cell function were examined in the present study. Islet cell surface antibody (ICSAb) was detected in sera from 6 of 40 patients with autoimmune thyroid disease (AITD) who were positive for thyroid microsomal autoantibodies (TMA). Furthermore, all of the ICSAb-positive patients had high TMA titers. In vitro study using isolated rat pancreatic islets revealed that TMA positive sera significantly suppressed glucose-induced insulin release. Only one of 19 (5%) AITD patients showed complement-dependent antibody-mediated cytotoxicity and only one of 6 AITD patients (17%) was positive for antibody-dependent cellular cytotoxicity. These results suggest that TMA has an effect on an antigen of the islet cell membrane in which insulin releasing mechanism might be involved.
胰岛素依赖型糖尿病常与器官特异性自身免疫性疾病和/或高滴度的器官特异性自身抗体相关。本研究检测了甲状腺自身抗体对胰岛细胞功能的影响。在40例甲状腺微粒体自身抗体（TMA）阳性的自身免疫性甲状腺疾病（AITD）患者中，有6例血清检测到胰岛细胞表面抗体（ICSAb）。此外，所有ICSAb阳性患者的TMA滴度都很高。使用分离的大鼠胰岛进行的体外研究表明，TMA阳性血清显著抑制葡萄糖诱导的胰岛素释放。19例（5%）AITD患者中只有1例表现出补体依赖性抗体介导的细胞毒性，6例AITD患者中只有1例（17%）抗体依赖性细胞毒性呈阳性。这些结果表明，TMA对胰岛细胞膜抗原具有影响，胰岛素释放机制可能参与其中。
