Cnudde F, Julvez J, Rivière J P
Acta Leprol. 1987 Apr-Jun;5(2):115-24.
Leprosy in Mayotte affects 480 persons in a population of 80,000 inhabitants. 229 patients have been treated every day by association of Rifampicin, Clofazimine and Isoniazide. This study make a clinical, histological and bacteriological valuation after treatment, during a period of 3 years. With paucibacillary patients, whom received 1 year of mean treatment and after 2 years under observation, histology for short-dated can stay positive and active. With multibacillary patients, whom received 26 months of mean treatment and most of the time after 1 year under observation, the all of morphological index is negative, sometime bacteriology is positive, less often than histology. For middle- and long-dated, histology should allow a good valuation for disease evolution, specially for interpolar leprosy patients.
马约特岛的麻风病在8万居民中有480人患病。每天有229名患者接受利福平、氯法齐明和异烟肼联合治疗。本研究在3年期间对治疗后的患者进行了临床、组织学和细菌学评估。对于少菌型患者，平均接受1年治疗，观察2年后，短期组织学检查可能仍呈阳性且活跃。对于多菌型患者，平均接受26个月治疗，大多数情况下观察1年后，所有形态学指标均为阴性，有时细菌学检查呈阳性，比组织学检查阳性的情况少见。对于中长期患者，组织学检查有助于很好地评估疾病进展，特别是对于中间型麻风患者。
