治疗后出现新的色素沉着提示磨皮术和非培养表皮细胞悬浮液技术治疗稳定型白癜风的疗效增加。

New Pigmentation After Medical Treatment Suggests Increased Efficacy of Dermabrasion and Noncultured Epidermal Cell Suspension Techniques in Stable Vitiligo.

机构信息

Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

Dermatol Surg. 2021 Apr 1;47(4):e142-e145. doi: 10.1097/DSS.0000000000002820.

DOI:10.1097/DSS.0000000000002820

PMID:33038103

Abstract

BACKGROUND

Stable vitiligo has been treated by dermabrasion and noncultured epidermal cell suspension (NCES) effectively. However, not all patches respond well.

OBJECTIVE

To investigate the efficacy of new pigmentation after medical treatment in the therapy of stable vitiligo.

MATERIALS AND METHODS

Medical records were retrospectively reviewed from October 2016 to March 2019, and 134 patients with stable vitiligo after medical therapy were further treated with NCES. They were divided into 2 groups: 70 patients in Group 1 had new pigmentation, whereas 64 patients in Group 2 did not. Repigmentation and satisfaction of patients and third-party assessors were evaluated at 3 and 6 months postoperatively.

RESULTS

Repigmentation was scored as excellent (≥76%), good (51%-75%), fair (26%-50%), or poor (≤25%). Repigmentation of the 2 groups at 6 months postoperatively was excellent in 82.9% versus 23.4%, good in 10.0% versus 15.6%, fair in 7.1% versus 13.0%, and poor in 0% versus 48.4%, respectively. A positive correlation between satisfaction and repigmentation was found.

CONCLUSION

New pigmentation after medical treatment suggests increased efficacy of NCES in treating stable vitiligo.

摘要

背景

稳定期白癜风已通过磨皮术和非培养表皮细胞悬液（NCES）得到有效治疗。然而，并非所有斑块都有良好反应。

目的

探讨药物治疗后新出现色素沉着对稳定期白癜风治疗效果的影响。

材料与方法

回顾性分析 2016 年 10 月至 2019 年 3 月期间因药物治疗后稳定期白癜风患者的病历资料，对其中 134 例患者进一步采用 NCES 治疗。将患者分为两组：70 例（组 1）患者有新的色素沉着，64 例（组 2）患者无新的色素沉着。术后 3 个月和 6 个月时评估患者和第三方评估者的复色和满意度。

结果

复色评分优秀（≥76%）、良好（51%-75%）、中等（26%-50%）或差（≤25%）。术后 6 个月时，组 1 的复色优秀率为 82.9%，组 2 为 23.4%；良好率组 1 为 10.0%，组 2 为 15.6%；中等率组 1 为 7.1%，组 2 为 13.0%；差率组 1 为 0%，组 2 为 48.4%。满意度与复色之间存在正相关。