Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Dermatol Ther. 2021 Jan;34(1):e14683. doi: 10.1111/dth.14683. Epub 2020 Dec 27.
Noncultured epidermal cell suspension (NCES) is a well-established surgical treatment modality for stable vitiligo. The outcome of this procedure significantly depends on the method of recipient site preparation, a critical step to achieve cosmetically acceptable repigmentation. To compare the efficacy of recipient site preparation using three methods namely, dermabrasion, cryoblister, and dermaroller followed by NCES in stable vitiligo. In this single-center, prospective, intra-patient, randomized clinical trial; 36 participants having at least three vitiligo patches in same anatomic region with minimum lesional stability of 1 year were randomized 1:1:1 for recipient site preparation using manual dermabrasion, cryoblister, and dermaroller followed by NCES. Patients were followed up at 4, 8, and 12 weeks and assessment of extent and pattern of repigmentation, color match and patient satisfaction were done. Among 36 patients, 22 (61.1%) were females; mean (SD) age was 28.33 (9.4) years. Dermabrasion and cryoblister techniques showed equal efficacy with respect to extent of repigmentation (>75% repigmentation; 55.6% vs 47.2%; P = .63) and patient satisfaction score (20.2 ± 9.6 vs 19.9 ± 7.9, P = .194). However, dermabrasion was superior to cryoblister in terms of rapidity (65% vs 32.5% at 4 weeks, P = .04) and color match (47.2% vs 19.4%, P = .004). Dermaroller had poor repigmentation outcomes compared to both dermabrasion and cryoblister. Cryoblister as a method of recipient site preparation is equally effective as manual dermabrasion in NCES for attaining good to excellent repigmentation, but with risk of hyperpigmentation. However, dermaroller is inferior to both dermabrasion and cryoblister.
非培养表皮细胞悬液 (NCES) 是一种成熟的稳定型白癜风手术治疗方法。该治疗的效果主要取决于接受治疗部位的准备方法，这是获得美容性可接受复色的关键步骤。本研究旨在比较三种方法，即磨皮术、冷冻水疱和微针滚轮，在稳定型白癜风患者中应用于接受治疗部位准备时的疗效。在这项单中心、前瞻性、患者内、随机临床试验中；将 36 名至少有三个相同解剖区域的白癜风斑块且病变稳定至少 1 年的患者，按 1:1:1 的比例随机分为磨皮术、冷冻水疱和微针滚轮组，分别应用这三种方法进行接受治疗部位准备，随后进行 NCES。在 4、8 和 12 周时对复色程度和模式、颜色匹配和患者满意度进行评估。36 名患者中，女性 22 例（61.1%）；平均（SD）年龄为 28.33（9.4）岁。磨皮术和冷冻水疱技术在复色程度（>75%复色；55.6%比 47.2%；P =.63）和患者满意度评分（20.2±9.6 比 19.9±7.9，P =.194）方面疗效相当。然而，磨皮术在复色速度（4 周时为 65%比 32.5%，P =.04）和颜色匹配（47.2%比 19.4%，P =.004）方面优于冷冻水疱。微针滚轮的复色效果明显劣于磨皮术和冷冻水疱。冷冻水疱作为一种接受治疗部位准备方法，在 NCES 中达到良好到极好复色的效果与手动磨皮术相当，但存在色素沉着过度的风险。然而，微针滚轮的效果明显劣于磨皮术和冷冻水疱。
