通过胸腺移植或用超免疫血清治疗预防裸鼠复发性疟疾。
Prevention of recrudescent malaria in nude mice by thymic grafting or by treatment with hyperimmune serum.
作者信息
Roberts D W, Rank R G, Weidanz W P, Finerty J F
出版信息
Infect Immun. 1977 Jun;16(3):821-6. doi: 10.1128/iai.16.3.821-826.1977.
Abstract
Nude mice died when infected with the normally avirulent malarial parasite Plasmodium berghei yoelii. Furthermore, malaria recrudesced in Nu/Nu mice after the termination of acute disease by treatment with clindamycin. Recrudescence was not observed in Nu/Nu mice that had been grafted with thymic tissue or treated with hyperimmune serum. Mice mad B cell deficient by treatment with anti-mu-chain serum also died when infected with P. berghei yoelii. The data suggest that a crucial role of the thymus in preventing recrudescent malaria in this model system is to provide a helper function in the production of protective antibody.
摘要
裸鼠感染通常无毒的疟原虫伯氏疟原虫约氏亚种后会死亡。此外，在用克林霉素治疗终止急性疾病后，Nu/Nu小鼠体内的疟疾复发。在移植了胸腺组织或用超免疫血清治疗的Nu/Nu小鼠中未观察到复发。用抗μ链血清处理导致B细胞缺陷的小鼠感染约氏疟原虫后也会死亡。数据表明，在该模型系统中，胸腺在预防复发性疟疾中的关键作用是在保护性抗体的产生中提供辅助功能。
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