通过胸腺移植或用超免疫血清治疗预防裸鼠复发性疟疾。
Prevention of recrudescent malaria in nude mice by thymic grafting or by treatment with hyperimmune serum.
作者信息
Roberts D W, Rank R G, Weidanz W P, Finerty J F
出版信息
Infect Immun. 1977 Jun;16(3):821-6. doi: 10.1128/iai.16.3.821-826.1977.
Abstract
Nude mice died when infected with the normally avirulent malarial parasite Plasmodium berghei yoelii. Furthermore, malaria recrudesced in Nu/Nu mice after the termination of acute disease by treatment with clindamycin. Recrudescence was not observed in Nu/Nu mice that had been grafted with thymic tissue or treated with hyperimmune serum. Mice mad B cell deficient by treatment with anti-mu-chain serum also died when infected with P. berghei yoelii. The data suggest that a crucial role of the thymus in preventing recrudescent malaria in this model system is to provide a helper function in the production of protective antibody.
摘要
裸鼠感染通常无毒的疟原虫伯氏疟原虫约氏亚种后会死亡。此外，在用克林霉素治疗终止急性疾病后，Nu/Nu小鼠体内的疟疾复发。在移植了胸腺组织或用超免疫血清治疗的Nu/Nu小鼠中未观察到复发。用抗μ链血清处理导致B细胞缺陷的小鼠感染约氏疟原虫后也会死亡。数据表明，在该模型系统中，胸腺在预防复发性疟疾中的关键作用是在保护性抗体的产生中提供辅助功能。
相似文献
1
Prevention of recrudescent malaria in nude mice by thymic grafting or by treatment with hyperimmune serum.通过胸腺移植或用超免疫血清治疗预防裸鼠复发性疟疾。
Infect Immun. 1977 Jun;16(3):821-6. doi: 10.1128/iai.16.3.821-826.1977.
2
Immunity to Plasmodium Berghei yoelii in mice. I. The course of infection in T cell and B cell deficient mice.小鼠对约氏疟原虫伯氏疟原虫的免疫。I. T细胞和B细胞缺陷小鼠的感染过程。
J Immunol. 1976 Nov;117(5 Pt.2):1999-2005.
3
Immunity to Plasmodium chabaudi adami in the B-cell-deficient mouse.B细胞缺陷小鼠对查巴迪疟原虫的免疫
Nature. 1981 Mar 12;290(5802):143-5. doi: 10.1038/290143a0.
4
Antibody-independent immunity to reinfection malaria in B-cell-deficient mice.B细胞缺陷小鼠中对再感染疟疾的非抗体依赖性免疫。
Infect Immun. 1983 Sep;41(3):1197-204. doi: 10.1128/iai.41.3.1197-1204.1983.
5
Proceedings: The passive transfer of immunity to Plasmodium berghei yoelii.
Trans R Soc Trop Med Hyg. 1975;69(4):426.
6
7
Adoptive transfer of immunity to Plasmodium berghei with immune T and B lymphocytes.用免疫T淋巴细胞和B淋巴细胞对伯氏疟原虫进行免疫的过继转移。
Infect Immun. 1976 Jul;14(1):184-90. doi: 10.1128/iai.14.1.184-190.1976.
8
Vitamin E-deficient diets enriched with fish oil suppress lethal Plasmodium yoelii infections in athymic and scid/bg mice.富含鱼油的维生素E缺乏饮食可抑制无胸腺小鼠和严重联合免疫缺陷/Beige小鼠中致死性约氏疟原虫感染。
Infect Immun. 1997 Jan;65(1):197-202. doi: 10.1128/iai.65.1.197-202.1997.
9
Experimental malarial infection. III--Protective role of antibodies in Plasmodium berghei infection in mice.
Indian J Malariol. 1984 Jun;21(1):45-51.
10
T-cell immunity to malaria in the B-cell deficient mouse.B细胞缺陷小鼠对疟疾的T细胞免疫
Am J Trop Med Hyg. 1979 Jan;28(1):1-3. doi: 10.4269/ajtmh.1979.28.1.
引用本文的文献
1
B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria.B 细胞固有表达 IFNλ 受体可抑制实验性血液期疟疾的急性体液免疫反应。
Virulence. 2020 Dec;11(1):594-606. doi: 10.1080/21505594.2020.1768329.
2
B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.B 细胞足以启动针对疟原虫感染的优势 CD4+Tfh 反应。
J Exp Med. 2020 Feb 3;217(2). doi: 10.1084/jem.20190849.
3
cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses.cGAS 介导的血期疟原虫控制促进了疟原虫特异性生发中心反应。
JCI Insight. 2018 Jan 25;3(2). doi: 10.1172/jci.insight.94142.
4
An Atypical Splenic B Cell Progenitor Population Supports Antibody Production during Plasmodium Infection in Mice.一种非典型脾B细胞祖细胞群体在小鼠疟原虫感染期间支持抗体产生。
J Immunol. 2016 Sep 1;197(5):1788-800. doi: 10.4049/jimmunol.1502199. Epub 2016 Jul 22.
5
The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection.共刺激分子ICOS调节宿主针对恰氏疟原虫AS株感染的Th1细胞和滤泡辅助性T细胞分化。
J Immunol. 2016 Jan 15;196(2):778-91. doi: 10.4049/jimmunol.1403206. Epub 2015 Dec 14.
6
Dried-leaf A practical malaria therapeutic for developing countries?干叶 一种适用于发展中国家的实用疟疾治疗方法？
World J Pharmacol. 2014 Dec 9;3(4):39-55. doi: 10.5497/wjp.v3.i4.39.
7
Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.为什么功能性原虫前期和红内期疟疾疫苗会失败：完全保护免疫接种和新型免疫模型的荟萃分析。
PLoS One. 2010 May 19;5(5):e10685. doi: 10.1371/journal.pone.0010685.
8
B cells are required for the switch from Th1- to Th2-regulated immune responses to Plasmodium chabaudi chabaudi infection.从针对恰氏疟原虫感染的Th1调节免疫反应转变为Th2调节免疫反应需要B细胞。
Infect Immun. 1994 Jun;62(6):2490-8. doi: 10.1128/iai.62.6.2490-2498.1994.
9
Host defenses in murine malaria: analysis of plasmodial infection-caused defects in macrophage microbicidal capacities.小鼠疟疾中的宿主防御：疟原虫感染导致巨噬细胞杀菌能力缺陷的分析。
Infect Immun. 1981 Jan;31(1):396-407. doi: 10.1128/iai.31.1.396-407.1981.
10
Host defenses in murine malaria: failure of vaccination with formolized blood parasites to protect athymic mice from Plasmodium berghei.鼠疟中的宿主防御：用甲醛固定的血液寄生虫进行疫苗接种未能保护无胸腺小鼠免受伯氏疟原虫感染。
Infect Immun. 1980 Aug;29(2):827-30. doi: 10.1128/iai.29.2.827-830.1980.
本文引用的文献
1
THE CUTANEOUS REACTIVITY OF GUINEA PIGS TO PURE PROTEIN ANTIGENS. I. A CRITICAL EVALUATION OF METHODS FOR THE INDUCTION OF DELAYED-TYPE HYPERSENSITIVITY TO PURE PROTEINS.豚鼠对纯蛋白抗原的皮肤反应性。I. 对诱导对纯蛋白迟发型超敏反应方法的批判性评价。
Int Arch Allergy Appl Immunol. 1964;25:279-303. doi: 10.1159/000229529.
2
Suppression of malaria (P. berghei) by milk.牛奶对疟疾（伯氏疟原虫）的抑制作用。
Br Med J. 1952 Dec 27;2(4799):1382-4. doi: 10.1136/bmj.2.4799.1382.
3
Plasmodium berghei infections in thymectomized rats.切除胸腺的大鼠感染伯氏疟原虫
Nature. 1968 Jul 20;219(5151):292-3. doi: 10.1038/219292a0.
4
Anti-thymocyte serum effects on Plasmodium berghei infection in rats.抗胸腺细胞血清对大鼠伯氏疟原虫感染的影响。
Immunology. 1970 Nov;19(5):759-66.
5
Impairment of antibody response and recovery in malarial rodents by antilymphocyte serum.抗淋巴细胞血清对感染疟疾啮齿动物抗体反应及恢复的损害
Nature. 1971 Feb 5;229(5284):429-30. doi: 10.1038/229429a0.
6
Plasmodium berghei infection in thymectomized rats.经胸腺切除的大鼠感染伯氏疟原虫。
Proc Soc Exp Biol Med. 1969 Jul;131(3):748-52. doi: 10.3181/00379727-131-33968.
7
Immunosuppression in mice injected with heterologous anti-immunoglobulin antisera.注射异种抗免疫球蛋白抗血清的小鼠中的免疫抑制。
J Immunol. 1972 Jan;108(1):282-5.
8
Babesia microti and Plasmodium berghei yoelii infections in nude mice.微小巴贝斯虫和约氏疟原虫在裸鼠中的感染
Nature. 1974 Nov 22;252(5481):328-9. doi: 10.1038/252328a0.
9
Potentiation of T-cell-mediated immunity by selective suppression of antibody formation with cyclophosphamide.通过环磷酰胺选择性抑制抗体形成增强T细胞介导的免疫
J Exp Med. 1974 Jun 1;139(6):1529-39. doi: 10.1084/jem.139.6.1529.
10
The immunologic response to plasmodium.
Am J Trop Med Hyg. 1972 Sep;21(5):713-21. doi: 10.4269/ajtmh.1972.21.713.
Zotero 插件