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冠状动脉搭桥术与常规冠状动脉旁路移植术的比较:利用和比较结果。

Hybrid Coronary Revascularization Versus Conventional Coronary Artery Bypass Surgery: Utilization and Comparative Outcomes.

机构信息

School of Public Health, University at Albany, State University of New York, NY (E.L.H., Y.W., K.C.).

Cardiac Surgical Division, Massachusetts General Hospital, Boston (T.M.S.).

出版信息

Circ Cardiovasc Interv. 2020 Oct;13(10):e009386. doi: 10.1161/CIRCINTERVENTIONS.120.009386. Epub 2020 Oct 12.

Abstract

BACKGROUND

Hybrid coronary revascularization (HCR) treats multivessel coronary artery disease by combining a minimally invasive surgical approach to the left anterior descending artery with percutaneous coronary intervention for non-left anterior descending diseased coronary arteries. The objective of this study is to compare HCR and conventional coronary artery bypass graft (CABG) surgery medium-term outcomes.

METHODS

Data from multivessel disease patients in New York's cardiac surgery and percutaneous coronary intervention registries in 2010 to 2016 were used to compare mortality and repeat revascularization rates for HCR and conventional CABG after using propensity matching to reduce selection bias.

RESULTS

There was a total of 303 HCR (0.80%) patients and 37 556 conventional CABG patients after exclusions. After propensity matching, the respective median follow-up times were 3.72 years and 3.76 years. There was no difference between HCR and conventional CABG in survival at 6 years (80.9% versus 85.8%%, adjusted hazard ratio, 1.44 [0.90-2.31]), but HCR had higher mortality excluding deaths during the first year (adjusted hazard ratio, 1.88 [1.10-3.23]). Conventional CABG patients were more likely to be free from repeat revascularization at 6 years than HCR patients (88.2% versus 76.6%; hazard ratio, 2.22 [1.44-3.42]).

CONCLUSIONS

HCR is rarely performed for patients with multivessel coronary artery disease. HCR and conventional CABG had no different 6-year mortality rates, but HCR had higher mortality after 1 year and higher rates of subsequent revascularization that were caused by both the need for repeat revascularization in the left anterior descending artery where minimally invasive CABG was performed, and in the coronary arteries where percutaneous coronary intervention was performed. Graphic Abstract: A graphic abstract is available for this article.

摘要

背景

杂交冠状动脉血运重建(HCR)通过结合微创方法治疗左前降支与经皮冠状动脉介入治疗非左前降支病变冠状动脉来治疗多支冠状动脉疾病。本研究的目的是比较 HCR 与常规冠状动脉旁路移植术(CABG)的中期结果。

方法

使用 2010 年至 2016 年纽约心脏手术和经皮冠状动脉介入治疗登记处的多支血管疾病患者的数据,通过倾向匹配来减少选择偏差,比较 HCR 和常规 CABG 的死亡率和再次血运重建率。

结果

排除后,共有 303 例 HCR(0.80%)患者和 37556 例常规 CABG 患者。在倾向匹配后,各自的中位随访时间分别为 3.72 年和 3.76 年。HCR 与常规 CABG 在 6 年生存率上无差异(80.9%对 85.8%,调整后的危险比为 1.44[0.90-2.31]),但 HCR 在排除第 1 年死亡的情况下死亡率更高(调整后的危险比为 1.88[1.10-3.23])。与 HCR 患者相比,常规 CABG 患者在 6 年内免于再次血运重建的可能性更高(88.2%对 76.6%;危险比为 2.22[1.44-3.42])。

结论

HCR 很少用于多支冠状动脉疾病患者。HCR 和常规 CABG 6 年死亡率无差异,但 HCR 1 年后死亡率较高,随后血运重建率较高,这是由于微创 CABG 治疗的左前降支需要再次血运重建,以及经皮冠状动脉介入治疗的冠状动脉需要再次血运重建所致。

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