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严重球部尿道损伤的改良内镜下一期复位术

A Modified Endoscopic Primary Realignment of Severe Bulbar Urethral Injury.

作者信息

Zhang Zejian, Fang Liekui, Chen Dong, Li Wei, Peng Naixiong, Thakker Parth U, Zhang Yuanyuan, Wang Xisheng

机构信息

Department of Urology, Shenzhen Long-hua District Central Hospital, The Affiliated Central Hospital of Shenzhen Long-hua District, Guangdong Medical University, Shenzhen, China.

Urinary Surgery Department of the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen Third People's Hospital, Shenzhen, China.

出版信息

J Endourol. 2021 Mar;35(3):335-341. doi: 10.1089/end.2020.0567. Epub 2021 Jan 29.

Abstract

Male urethral injury is a common urologic emergency in developing countries. Whether early or late treatment of urethral injuries is often multifactorial and controversial. The goal of this study is to determine whether early realignment can reduce postsurgical complications and evaluate the clinical feasibility of emergency endoscopic urethroplasty using single rigid ureteroscopy in the treatment of bulbar urethral severe injury. Between September 2013 and March 2019, 15 male adult patients (mean age 35 years; from 21 to 62 years) with severe bulbar urethral injury were enrolled into the current study. The patients mainly presented with dysuria or painful urination (15/15, 100%), urethral bleeding (13/15, 86.7%), and urinary retention (11/15, 73.3%). Six of them had swelling of perineal or scrotal soft tissue, while four had testicular contusion. No pelvic fracture was found in all cases with CT scanning of the pelvic cavity. The bulbar urethral at grade IV was confirmed to be completely ruptured in all cases by endoscopy during operation. The modified endoscopic primary realignment was performed. This new urethral repair technique was effectively performed in all patients and none converted to open operation. Mean operation time was 42.3 ± 11.5 minutes (28-52 minutes) and the mean Foley catheter indwelling time was 34.5 ± 6.9 days (28-42 days). During a follow-up of 41.3 ± 22.8 months (12-64 months), mild urethral strictures (grade I) (19.7 ± 9.5 weeks, 10-27 weeks postsurgery) developed in 8 patients (53.3%) and then were all improved 2.1 ± 0.8 months (1.3-2.9 months) after periodic dilatations of the urethra (4-10 times). Erectile dysfunction (ED) occurred in three patients (20%) after surgery, who recovered from mild ED to normal by administration with oral sildenafil (100 mg, three times a week) for 12 weeks. The International Index of Erectile Function-5 (IIEF-5) score was significantly improved after surgery ( ± SD, 25 ± 3) compared with before (16.4 ± 3.5) ( < 0.05). No incontinence and other complications occurred in all cases. Early endoscopic realignment via suprapubic puncture cystostomy by single rigid ureteroscopy provides an effective, feasible, and safe procedure for severe bulbar urethral injury.

摘要

男性尿道损伤是发展中国家常见的泌尿外科急症。尿道损伤的早期或晚期治疗往往受多种因素影响,且存在争议。本研究的目的是确定早期复位是否能减少术后并发症,并评估使用单根硬性输尿管镜进行急诊内镜尿道成形术治疗球部尿道严重损伤的临床可行性。2013年9月至2019年3月,15例成年男性(平均年龄35岁,21至62岁)球部尿道严重损伤患者纳入本研究。患者主要表现为排尿困难或尿痛(15/15,100%)、尿道出血(13/15,86.7%)和尿潴留(11/15,73.3%)。其中6例有会阴或阴囊软组织肿胀,4例有睾丸挫伤。所有盆腔CT扫描病例均未发现骨盆骨折。术中经内镜证实所有病例的IV级球部尿道完全断裂。实施改良内镜一期复位术。该新型尿道修复技术在所有患者中均有效实施,无一例转为开放手术。平均手术时间为42.3±11.5分钟(28至52分钟),平均Foley导尿管留置时间为34.5±6.9天(28至42天)。在41.3±22.8个月(12至64个月)的随访中,8例患者(53.3%)出现轻度尿道狭窄(I级)(术后19.7±9.5周,10至27周),经定期尿道扩张(4至10次)后,2.1±0.8个月(1.3至2.9个月)均得到改善。3例患者(20%)术后出现勃起功能障碍(ED),口服西地那非(100mg,每周3次)12周后从轻度ED恢复至正常。与术前(16.4±3.5)相比,术后国际勃起功能指数-5(IIEF-5)评分显著改善(±标准差,25±3)(P<0.05)。所有病例均未发生尿失禁及其他并发症。经耻骨上穿刺膀胱造瘘,使用单根硬性输尿管镜进行早期内镜复位术,为球部尿道严重损伤提供了一种有效、可行且安全的手术方法。

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