Department of Urology, General Hospital of Athens "G.Gennimatas", Athens, Greece.
Department of Urology, General Hospital of Lakonia, Sparta, Greece.
Urologia. 2021 May;88(2):110-114. doi: 10.1177/0391560320964611. Epub 2020 Oct 10.
Radical prostatectomy represents the most popular method of prostate cancer treatment, including cases with high-risk and locally advanced cancer. Besides, men with this disease often experience lower urinary tract symptoms (LUTS) and report high International Prostate Symptom Scores (IPSS), pathological post-void residual (PVR) urine volumes and low levels of maximum urinary flow rates (Qmax). In this study we assessed the effect of radical prostatectomy on the above parameters in patients with high-risk and locally advanced disease.
A number of 240 individuals were enrolled in the study. Patients that required any post-operative manipulation up to the completion of 12 months after surgery were excluded. All patients were assessed pre- and post-operatively at 3, 6 and 12 months. Evaluation included IPSS, Qmax and PVR.
Mean age was 66.8 years. Mean PSA value was 12.7 ng/ml and mean Gleason score was 7.9. At baseline 41.3% of the patients had Qmax ⩽10 and 42.5% had IPSS >8. There was a significant increase in Qmax during the follow-up (median value was 12 at baseline and increased to 21 at 12 months). Also, IPSS and PVR decreased significantly during the follow-up. IPSS median value decreased from 9 at baseline to 5 at 12 months. Improvement was observed in all grades of symptoms.
根治性前列腺切除术是治疗前列腺癌的最常用方法，包括高危和局部晚期癌症病例。此外，患有这种疾病的男性经常经历下尿路症状（LUTS），并报告国际前列腺症状评分（IPSS）较高、病理排空后残余尿量（PVR）较高和最大尿流率（Qmax）较低。在这项研究中，我们评估了根治性前列腺切除术对高危和局部晚期疾病患者上述参数的影响。
共有 240 名患者入组研究。排除了需要任何术后操作直至手术后 12 个月完成的患者。所有患者在术前、术后 3、6 和 12 个月进行评估。评估包括 IPSS、Qmax 和 PVR。
平均年龄为 66.8 岁。平均 PSA 值为 12.7ng/ml，平均 Gleason 评分为 7.9。基线时，41.3%的患者 Qmax ⩽10，42.5%的患者 IPSS >8。在随访期间，Qmax 显著增加（基线时中位数为 12，12 个月时增加至 21）。此外，IPSS 和 PVR 在随访期间显著下降。IPSS 中位数从基线时的 9 降至 12 个月时的 5。所有症状等级均观察到改善。
