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减重手术后最大体重减轻的时间:一项中国患者的研究。

Timing of Maximal Weight Reduction Following Bariatric Surgery: A Study in Chinese Patients.

机构信息

Department of Bariatric & Metabolic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

出版信息

Front Endocrinol (Lausanne). 2020 Sep 15;11:615. doi: 10.3389/fendo.2020.00615. eCollection 2020.

Abstract

Bariatric surgery is a well-received treatment for obesity with maximal weight loss at 12-36 months postoperatively. We investigated the effect of early bariatric surgery on weight reduction of Chinese patients in accordance with their preoperation characteristics. Altogether, 409 patients with obesity from a prospective cohort in a single bariatric center were enrolled retrospectively and evaluated for up to 4 years. Measurements obtained included surgery type, duration of diabetic condition, besides the usual body mass index data tuple. Weight reduction was expressed as percent total weight loss (%TWL) and percent excess weight loss (%EWL). RYGB or SG were performed laparoscopically without mortality or complications. BMI generally plateaued at 12 months, having decreased at a mean of 8.78 kg/m. Successful weight loss of >25% TWL was achieved by 35.16, 49.03, 39.22, 27.74, 20.83% of patients at 6, 12, 24, 36, and 48 months after surgery. Overall, 52.91% of our patients had lost 100% of their excess weight at 12 months, although there was a rather wide range among individuals. Similar variability was revealed in women of child-bearing age. Chinese patients undergoing bariatric surgery tend to achieve maximal weight loss and stabilization between 12 and 24 months postoperatively, instead of at >2 years. The finding of the shorter stabilization interval has importance to earlier intervention of weight loss related conditions and women's conception planning.

摘要

减重手术是一种广受欢迎的肥胖治疗方法,术后 12-36 个月可达到最大减重效果。我们根据中国患者术前特点,研究了早期减重手术对体重减轻的影响。

我们回顾性地纳入了来自单中心前瞻性队列中的 409 例肥胖患者,并进行了长达 4 年的随访。测量指标包括手术类型、糖尿病病程时间,以及常规的体重指数数据。体重减轻以总体重减轻百分比(%TWL)和超重体重减轻百分比(%EWL)表示。

RYGB 或 SG 均通过腹腔镜完成,无死亡或并发症。BMI 通常在 12 个月时达到平台期,平均下降 8.78kg/m。术后 6、12、24、36 和 48 个月,分别有 35.16%、49.03%、39.22%、27.74%和 20.83%的患者成功实现>25%的 TWL 减重。总体而言,52.91%的患者在术后 12 个月时已减去 100%的超重体重,尽管个体之间差异较大。在育龄女性中也存在类似的变异性。

中国患者接受减重手术后,倾向于在术后 12-24 个月达到最大减重效果和稳定状态,而不是在>2 年后。这一发现提示,对于与体重相关的疾病和女性妊娠计划,更早进行干预可能更为重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a64/7522214/d5a425c442dd/fendo-11-00615-g0001.jpg

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