Coon M J, Koop D R
Arch Toxicol. 1987;60(1-3):16-21. doi: 10.1007/BF00296940.
Of the family of P-450 cytochromes occurring in rabbit liver microsomes, only isozyme 3a (P-450ALC) is induced by alcohol administration and is effective in catalyzing the reaction: ethanol +02+NADPH+H+----acetaldehyde +2H2O+NADP+. As judged by immunochemical quantitation, P-450ALC is also induced in the animals by other diverse agents, including imidazole, trichloroethylene, acetone, pyrazole, and isoniazid. Evidence has been obtained for the occurrence of a protein immunochemically related to P-450ALC in human liver microsomes and of a similar alcohol-inducible protein in the rat and in the normal and alcohol dehydrogenase-deficient deer-mouse. P-450ALC catalyzes the activation of foreign compounds such as acetaminophen, various nitrosamines, and carbon tetrachloride and is therefore believed to play an important role in the enhanced toxicity of these substances accompanying alcohol administration.
在兔肝微粒体中存在的细胞色素P-450家族中，只有同工酶3a（P-450ALC）可由酒精给药诱导产生，并且在催化反应中有效：乙醇+O₂+NADPH+H⁺→乙醛+2H₂O+NADP⁺。通过免疫化学定量判断，P-450ALC在动物中也可由其他多种药物诱导产生，包括咪唑、三氯乙烯、丙酮、吡唑和异烟肼。已获得证据表明，在人肝微粒体中存在一种与P-450ALC免疫化学相关的蛋白质，在大鼠以及正常和缺乏乙醇脱氢酶的鹿鼠中也存在类似的酒精诱导蛋白。P-450ALC催化诸如对乙酰氨基酚、各种亚硝胺和四氯化碳等外来化合物的活化，因此被认为在酒精给药时这些物质毒性增强中起重要作用。
