Sarno Sabrina, Cerrone Margherita, Gigantino Vincenzo, Scognamiglio Giosuè, Cantile Monica, Botti Gerardo, Di Bonito Maurizio
Università degli Studi di Napoli Federico II Naples, Italy.
Pathology Unit, Istituto Nazionale Tumori-Irccs-Fondazione G. Pascale Naples, Italy.
Int J Clin Exp Pathol. 2020 Sep 1;13(9):2348-2351. eCollection 2020.
Phyllodes tumor of the breast is a rare fibroepithelial lesion characterized by a propensity for local recurrence and distant metastasis. Its histologic classification, based on morphology, mitotic index and tumor margin, includes malignant, borderline, and benign. These tumors show similar cellular morphology, which may contribute to difficulty in classifying them histologically and in prediction of their clinical behavior. Thus, the identification of new biomarkers detectable also by in situ methods has become indispensable. Paralogous HOX13 genes (HOX A13, HOX B13, HOX C13 and HOX D13) play a relevant role in tumor development and progression in particular in breast cancer. In this study we analyzed the immunohistochemical expression of paralogous HOX13 homeoproteins on a phyllodes tumor case series to validate their usefulness in histologic classification.
乳腺叶状肿瘤是一种罕见的纤维上皮性病变，其特点是易于局部复发和远处转移。根据形态学、有丝分裂指数和肿瘤边界进行的组织学分类包括恶性、交界性和良性。这些肿瘤表现出相似的细胞形态，这可能导致在组织学分类和预测其临床行为方面存在困难。因此，鉴定也可通过原位方法检测到的新生物标志物变得不可或缺。同源HOX13基因（HOX A13、HOX B13、HOX C13和HOX D13）在肿瘤发生和进展中，特别是在乳腺癌中发挥着重要作用。在本研究中，我们分析了同源HOX13同源蛋白在一系列叶状肿瘤病例中的免疫组化表达，以验证它们在组织学分类中的实用性。
