Vignon F, Bouton M M, Rochefort H
Biochem Biophys Res Commun. 1987 Aug 14;146(3):1502-8. doi: 10.1016/0006-291x(87)90819-9.
The antiproliferative effect of antiestrogens in breast cancer is believed to be entirely due to the inhibition of estrogen induced growth. We show here that non-steroidal antiestrogens inhibit the growth of the human breast cancer MCF7 cells in the complete absence of estrogens (phenol-red-free medium) when cell proliferation is stimulated by insulin or epidermal growth factor. This non-antiestrogenic effect of antiestrogens is, however, mediated by accessible estrogen receptor sites, as it is not observed in receptor negative hormone-independent breast cancers, and is rescued by estradiol but not by insulin. We conclude that antiestrogens inhibit cell proliferation by inhibiting growth factor action as well as estrogen action and that in both cases, accessible estrogen receptors are required.
抗雌激素药物在乳腺癌中的抗增殖作用被认为完全归因于对雌激素诱导生长的抑制。我们在此表明，当细胞增殖由胰岛素或表皮生长因子刺激时，非甾体类抗雌激素药物在完全不存在雌激素（无酚红培养基）的情况下抑制人乳腺癌MCF7细胞的生长。然而，抗雌激素药物的这种非抗雌激素作用是由可及的雌激素受体位点介导的，因为在受体阴性的激素非依赖性乳腺癌中未观察到这种作用，并且该作用可被雌二醇挽救，但不能被胰岛素挽救。我们得出结论，抗雌激素药物通过抑制生长因子作用以及雌激素作用来抑制细胞增殖，并且在这两种情况下，都需要可及的雌激素受体。
