Lin Yong, Mao Chi, Hou Dan, Chang Xiao-Rong, Zhang Jun-Hua, Zhao Xian-Yin
Department of Stomatology, Puyang Oilfield General Hospital. Puyang 457001, Henan Province, China. E-mail:
Shanghai Kou Qiang Yi Xue. 2020 Jun;29(3):316-320.
To investigate the effect of autologous concentrated growth factor fibrin solution combined with Bio-Oss bone powder on mucosal healing and bone regeneration after oral implanted guided bone regeneration.
From October 2016 to December 2018, 83 patients with maxillary single anterior tooth loss and labial bone defect were treated, they were divided into two groups. Patients in the experimental group (42 cases) received autologous concentrated growth factor fibrin solution + Bio-Oss bone powder, while patients in the control group (41 cases) received Bio-Oss bone powder alone. The degree of mucosal healing, implant success, bone defect regeneration, pain and other complications were followed up 7 days, 6 weeks and 1 year after operation. The success rate and complications of the two groups were observed, as well as the differences of mucosal color, swelling degree, bleeding index, depth of probing, attachment loss, height of bone graft and thickness of bone formation were measured and recorded. Statistical analysis was performed using SPSS 25.0 software package.
There was no significant difference in the success rate of implants between the two groups (95.24% vs 97.56%, P>0.05). The complication rate of the experimental group was significantly lower than that of the control group (2.38% vs 14.63%, P<0.05). The mucosal color and swelling degree scores of the experimental group were significantly lower than those of the control group [(0.65±0.03) points vs (2.01±0.15) points, (1.10±0.37) points vs (2.69±0.54) points, P<0.05], and the bleeding index, probing depth, and attachment loss were significantly lower than the control group [(0.35±0.05) vs (0.49±0.09), (3.39±0.62) mm vs (4.41±0.95) mm, (3.02±0.66) mm vs (5.31±0.91) mm, P<0.05], bone graft height and osteogenesis height were significantly higher than the control group [(2.61±0.50) mm vs (2.20±0.31) mm, (2.53±0.34) mm vs (2.02±0.27) mm, P<0.05]. The degree of postoperative pain in the experimental group was significantly lower than that in the control group(P<0.05).
Rich self-concentrating growth factor fibrin solution combined with Bio-Oss bone powder can effectively promote mucosal healing and bone regeneration after oral implant-guided bone regeneration, and reduce postoperative pain and complications.
探讨自体浓缩生长因子纤维蛋白溶液联合Bio-Oss骨粉对口腔种植引导骨再生术后黏膜愈合及骨再生的影响。
选取2016年10月至2018年12月上颌单颗前牙缺失伴唇侧骨缺损患者83例，分为两组。实验组（42例）患者接受自体浓缩生长因子纤维蛋白溶液+Bio-Oss骨粉治疗，对照组（41例）患者仅接受Bio-Oss骨粉治疗。术后7天、6周及1年随访观察黏膜愈合程度、种植成功率、骨缺损再生情况、疼痛及其他并发症。观察两组的成功率及并发症，同时测量并记录黏膜颜色、肿胀程度、出血指数、探诊深度、附着丧失、植骨高度及骨形成厚度的差异。采用SPSS 25.0软件包进行统计学分析。
两组种植成功率差异无统计学意义（95.24% vs 97.56%，P>0.05）。实验组并发症发生率显著低于对照组（2.38% vs 14.63%，P<0.05）。实验组黏膜颜色及肿胀程度评分显著低于对照组[（0.65±0.03）分 vs （2.01±0.15）分，（1.10±0.37）分 vs （2.69±0.54）分，P<0.05]，出血指数、探诊深度及附着丧失显著低于对照组[（0.35±0.05） vs （0.49±0.09），（3.39±0.62）mm vs （4.41±0.95）mm，（3.02±0.66）mm vs （5.31±0.91）mm，P<0.05]，植骨高度及成骨高度显著高于对照组[（2.61±0.50）mm vs （2.20±0.31）mm，（2.53±0.34）mm vs （2.02±0.27）mm，P<0.05]。实验组术后疼痛程度显著低于对照组（P<0.05）。
富自体浓缩生长因子纤维蛋白溶液联合Bio-Oss骨粉可有效促进口腔种植引导骨再生术后黏膜愈合及骨再生，减轻术后疼痛并减少并发症。
