Wang Yichao, Zhou Shengliang, Liu Xueting, Rui Shu, Li Zhihui, Zhu Jingqiang, Wei Tao
Department of Thyroid, Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu, China.
West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Head Neck. 2021 Jan;43(1):345-353. doi: 10.1002/hed.26486. Epub 2020 Oct 12.
To conduct a meta-analysis to compare the safety and efficacy of transoral endoscopic thyroidectomy vestibular approach (TOETVA) with conventional open thyroidectomy (COT).
MEDLINE, EMBASE, Science Citation Index Expanded, and the Cochrane Central Register of Controlled Trials in the Cochrane Library from January 2007 to March 2020 were searched to identify studies comparing TOETVA and COT.
Six eligible nonrandomized studies involving 1151 patients were included. Meta-analysis results revealed that TOETVA group had a significantly longer operative time (weighted mean difference [WMD], 66.09; 95% confidence interval [CI], 35.22-96.96; P < .0001) and larger amount of drainage (WMD, 98; 95% CI, 20.14-175.86; P = .01). There were no significant differences in terms of postoperative outcomes.
TOETVA appears to be as feasible and safe as the COT for the treatment of patients with benign thyroid nodules and selected differential thyroid carcinomas.
进行一项荟萃分析，比较经口内镜甲状腺切除术前庭入路（TOETVA）与传统开放性甲状腺切除术（COT）的安全性和有效性。
检索2007年1月至2020年3月期间MEDLINE、EMBASE、科学引文索引扩展版以及Cochrane图书馆中的Cochrane对照试验中心注册库，以识别比较TOETVA和COT的研究。
纳入了6项符合条件的非随机研究，涉及1151例患者。荟萃分析结果显示，TOETVA组的手术时间明显更长（加权平均差[WMD]，66.09；95%置信区间[CI]，35.22 - 96.96；P <.0001），引流量更大（WMD，98；95% CI，20.14 - 175.86；P = 0.01）。术后结果方面无显著差异。
对于治疗良性甲状腺结节和特定分化型甲状腺癌患者，TOETVA似乎与COT一样可行且安全。
