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与帕唑帕尼相关的伴有后部可逆性脑病综合征的子宫肉瘤。

Uterine sarcoma with posterior reversible encephalopathy syndrome associated with pazopanib.

机构信息

Department of Pharmacy, Kagawa University Hospital, Kagawa, Japan.

Emergency Medical Centre, Kagawa University Hospital, Kagawa, Japan.

出版信息

J Clin Pharm Ther. 2021 Feb;46(1):223-226. doi: 10.1111/jcpt.13261. Epub 2020 Oct 12.

DOI:10.1111/jcpt.13261
PMID:33044009
Abstract

WHAT IS KNOWN AND OBJECTIVE

Our objective is to report on a case of posterior reversible encephalopathy syndrome associated with pazopanib.

CASE DESCRIPTION

A 64-year-old patient with uterine sarcoma developed PRES 3 days after pazopanib was initiated. After the discontinuation of pazopanib, the symptoms of PRES improved.

WHAT IS NEW AND CONCLUSION

The first report worldwide to describe a patient with uterine sarcoma experiencing PRES caused by pazopanib. Patients with uterine sarcoma may experience PRES, even in the early phase of pazopanib therapy.

摘要

已知和目的

我们的目的是报告一例与帕唑帕尼相关的后部可逆性脑病综合征。

病例描述

一名 64 岁的子宫肉瘤患者在开始使用帕唑帕尼后 3 天出现 PRES。停止使用帕唑帕尼后，PRES 的症状有所改善。

新发现和结论

这是全球首例报告的子宫肉瘤患者因帕唑帕尼引起 PRES 的病例。子宫肉瘤患者可能会出现 PRES，即使在帕唑帕尼治疗的早期阶段也是如此。

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