Sansonetti P J, Charmot G
Biomed Pharmacother. 1987;41(4):167-71.
Resistance of Plasmodium falciparum to antimalarial drugs is a growing worldwide problem in endemic areas. This is particularly obvious with chloroquine resistance which has been spreading throughout Africa since 1978. Initially localized on the Eastern coast of the continent, it has recently reached the Atlantic coast although Western Africa is as yet unaffected. This resistance has most probably arisen in the autochtonous population under the selective pressure of insufficient curative treatments as a result of self medication. It is most prevalent in children of urban areas but is often revealed in non immune expatriates. In addition, moderately resistant parasites in expatriates under chemoprophylaxis may lead to an insidious clinical form with a low or even negative parasitemia which raises diagnostic problems. Prophylactic and therapeutic schemes must take this new situation into account.
恶性疟原虫对抗疟药物的耐药性在流行地区已成为一个日益严重的全球性问题。氯喹耐药性问题尤为明显，自1978年以来，这种耐药性一直在非洲蔓延。最初局限于非洲大陆东海岸，最近已蔓延至大西洋海岸，不过西非尚未受到影响。这种耐药性很可能是由于自我用药导致治疗不充分，在当地人群的选择压力下产生的。它在城市地区的儿童中最为普遍，但在非免疫的外籍人员中也经常出现。此外，接受化学预防的外籍人员中的中度耐药寄生虫可能导致一种隐匿的临床形式，其寄生虫血症较低甚至为阴性，这就带来了诊断问题。预防和治疗方案必须考虑到这种新情况。
