Institute of Botany, Heinrich-Heine University, Düsseldorf, D-40225, Germany.
Plant Science Research Laboratory (LRSV), UMR5546 CNRS/Université Toulouse 3, Auzeville-Tolosane, 31320, France.
Biol Cell. 2021 Jan;113(1):1-13. doi: 10.1111/boc.202000118. Epub 2020 Nov 26.
The removal of transmembrane proteins from the plasma membrane via endocytosis has emerged as powerful strategy in the regulation of receptor signalling and molecule transport. In the last decade, IRON-REGULATED TRANSPORTER1 (IRT1) has been established as one of the key plant model proteins for studying endomembrane trafficking. The use of IRT1 and additional other metal transporters has uncovered novel factors involved in plant endocytosis and facilitated a better understanding of the role of endocytosis in the fine balancing of plant metal homoeostasis. In this review, we outline the specifics of plant endocytosis compared to what is known in yeast and mammals, and based on several examples, we demonstrate how studying metal transport has contributed to extending our knowledge of endocytic trafficking by shedding light on novel regulatory mechanisms and factors.
通过内吞作用从质膜中去除跨膜蛋白已成为调节受体信号和分子运输的有效策略。在过去的十年中，IRON-REGULATED TRANSPORTER1（IRT1）已被确立为研究内膜运输的关键植物模型蛋白之一。IRT1 和其他一些金属转运蛋白的使用揭示了参与植物内吞作用的新因子，并促进了对内吞作用在植物金属稳态精细平衡中的作用的更好理解。在这篇综述中，我们概述了与酵母和哺乳动物相比植物内吞作用的具体特点，并基于几个例子，展示了研究金属运输如何通过揭示新的调节机制和因子来促进我们对内吞作用运输的知识扩展。
