Perlow M J, Kokoris G, Gibson M J, Silverman A J, Kreiger D T, Zimmerman E A
Brain Res. 1987 Jul 7;415(1):158-62. doi: 10.1016/0006-8993(87)90280-0.
Transplantation of normal fetal gonadotropin-releasing hormone (GnRH) neurons from the accessory olfactory bulb (AOB) to the third ventricle of GnRH-deficient adult mutant mice reverses the genetically determined reduction in pituitary hormones and poorly developed gonads. The transplanted heterotopic AOB neurons adapt their morphology and secretory functions to what is observed with preoptic GnRH neurons when transplanted into deficient mice and in the normal intact mature animal. This suggests the presence of median eminence trophic factors affecting the growth, terminal sprouting, and functional behavior of the transplanted neurons.
将来自副嗅球（AOB）的正常胎儿促性腺激素释放激素（GnRH）神经元移植到GnRH缺乏的成年突变小鼠的第三脑室，可逆转由基因决定的垂体激素减少和性腺发育不良的情况。当移植到缺乏GnRH的小鼠和正常完整的成熟动物体内时，移植的异位AOB神经元会使其形态和分泌功能适应视前GnRH神经元所观察到的情况。这表明存在影响移植神经元生长、终末发芽和功能行为的正中隆起营养因子。
