热性惊厥患儿维生素K状态的评估。

The evaluation of vitamin K status in children with febrile seizure.

作者信息

Carman Kürşat Bora, Karal Yasemin, Gülen Mert Gül, Ekici Arzu, Perk Peren, Yarar Coşkun, Nuhoğlu Çağatay, Bozan Gürkan, Kılıç Ömer, Dinleyici Meltem, Şahin Sabiha, Atay Emrah, Tokdemir Uğur, Demir Baver, Dinleyici Ener Çağrı, Study Group Dinleyici Ec Efes

机构信息

Department of Pediatric Neurology, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey.

Department of Pediatrics, Trakya University School of Medicine, Edirne, Turkey.

出版信息

Balkan Med J. 2021 Mar;38(2):116-120. doi: 10.4274/balkanmedj.galenos.2020.2020.5.70.

DOI:10.4274/balkanmedj.galenos.2020.2020.5.70

PMID:33045823

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8909255/

Abstract

BACKGROUND

Febrile seizure is the most common neurological disorder in childhood. The exact pathophysiology of febrile seizures is unknown. Recent studies showed the role of vitamin K in nonhematological and inflammatory disorders. This study aimed to investigate the serum vitamin K levels in children with febrile seizures.

AIMS

To evaluate vitamin K levels in children with febrile seizures.

STUDY DESIGN

Prospective case-control study.

METHODS

This multicenter study examined representative populations in 8 different cities in Turkey between April 1, 2018 and April 1, 2019. Blood samples were taken from all children at presentation. Vitamin K1, vitamin K2, tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6 levels were determined by enzyme-linked immunosorbent assay.

RESULTS

A total of 155 children were included in the study-84 children with febrile seizures and 71 children in febrile control group. Serum vitamin K1 and vitamin K2 levels were also higher in children with febrile seizures than in the controls. The results of statistical analysis showed that vitamin K1 and vitamin K2 levels were correlated with tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6 levels. The median vitamin K1 and vitamin K2 levels of children experiencing their first febrile seizure were higher than those in children with recurrent febrile seizures. Type of febrile seizure has no effect on serum vitamin K1 and vitamin K2 levels.

CONCLUSION

In children with febrile seizures, vitamin K levels are higher than those in the control group. These new findings may contribute to elucidating the etiopathogenesis of febrile seizures.

摘要

背景

热性惊厥是儿童期最常见的神经系统疾病。热性惊厥的确切病理生理学尚不清楚。最近的研究表明维生素K在非血液学和炎症性疾病中的作用。本研究旨在调查热性惊厥患儿的血清维生素K水平。

目的

评估热性惊厥患儿的维生素K水平。

研究设计

前瞻性病例对照研究。

方法

这项多中心研究在2018年4月1日至2019年4月1日期间对土耳其8个不同城市的代表性人群进行了调查。所有儿童在就诊时采集血样。采用酶联免疫吸附测定法测定维生素K1、维生素K2、肿瘤坏死因子-α、白细胞介素1β和白细胞介素6水平。

结果

共有155名儿童纳入研究，其中84名热性惊厥患儿，71名发热对照组儿童。热性惊厥患儿的血清维生素K1和维生素K2水平也高于对照组。统计分析结果表明，维生素K1和维生素K2水平与肿瘤坏死因子-α、白细胞介素1β和白细胞介素6水平相关。首次发生热性惊厥的儿童的维生素K1和维生素K2水平中位数高于复发性热性惊厥儿童。热性惊厥类型对血清维生素K1和维生素K2水平无影响。