Department of Microbiology, The Ohio State University, Columbus, OH 43210, USA; The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
Department of Microbiology, The Ohio State University, Columbus, OH 43210, USA; The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
Trends Microbiol. 2021 Jan;29(1):4-5. doi: 10.1016/j.tim.2020.09.011. Epub 2020 Oct 10.
In prokaryotes, transcription-translation coupling is thought to guarantee the synthesis of high-quality mRNAs and surveil foreign genes. Surprisingly, Johnson et al. show that translation is uncoupled from transcription in Bacillus subtilis, arguing that bacteria utilize very diverse gene expression strategies to meet their unique regulatory needs.
在原核生物中,转录-翻译偶联被认为能保证高质量 mRNA 的合成和监控外来基因。令人惊讶的是,Johnson 等人表明枯草芽孢杆菌中转录和翻译是解偶联的,这表明细菌利用非常多样化的基因表达策略来满足其独特的调控需求。