二甲双胍对糖尿病和非糖尿病小鼠结核分枝杆菌感染的不同影响。
Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice.
机构信息
Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns and Townsville, Queensland, Australia.
College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia.
出版信息
Antimicrob Agents Chemother. 2020 Dec 16;65(1). doi: 10.1128/AAC.01422-20.
Abstract
Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.
摘要
合并 2 型糖尿病给全球结核病控制带来了巨大挑战。在这里，我们评估了抗糖尿病药物二甲双胍（MET）在感染极低剂量的小鼠中的疗效。与糖尿病小鼠不同，接受相同治疗浓度 MET 的感染非糖尿病小鼠表现出显著更高的疾病负担。这需要进一步的研究来调查 MET 在糖尿病和非糖尿病个体中对抗结核病的不同疗效。
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