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误诊为纵隔原发性腺癌的胸段脊索瘤

Thoracic Chordoma Misdiagnosed as Primary Adenocarcinoma of the Mediastinum.

作者信息

Yoon Seung Keun, Moon Mi Hyoung, Moon Seok Whan

机构信息

Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

出版信息

J Chest Surg. 2021 Apr 5;54(2):158-161. doi: 10.5090/jcs.20.030.

DOI:10.5090/jcs.20.030
PMID:33046672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8038888/
Abstract

Chordoma is a rare malignant bone tumor originating from the embryonic notochord. Herein, we present a case of thoracic chordoma located at T3-T5 that was misdiagnosed as primary mediastinal adenocarcinoma. The patient underwent neoadjuvant chemoradiation and the disease showed little response. Due to vertebral body invasion, we performed en bloc mass removal and partial corpectomy (T4-5) in collaboration with orthopedic surgeons.

摘要

脊索瘤是一种起源于胚胎脊索的罕见恶性骨肿瘤。在此，我们报告一例位于T3 - T5的胸椎脊索瘤，该病例最初被误诊为原发性纵隔腺癌。患者接受了新辅助放化疗，但病情反应不佳。由于椎体受侵，我们与骨科医生合作，实施了整块肿物切除及部分椎体切除术（T4 - 5）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a106/8038888/acb7d5e54bd8/jcs-54-2-158-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a106/8038888/1699060e0b42/jcs-54-2-158-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a106/8038888/acb7d5e54bd8/jcs-54-2-158-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a106/8038888/1699060e0b42/jcs-54-2-158-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a106/8038888/acb7d5e54bd8/jcs-54-2-158-f2.jpg

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引用本文的文献

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Unusual Presentation of Thoracic Chordoma with Spinal Epidural Hematoma: A Rare Case Report and PRISMA-Driven Systematic Review.伴有脊髓硬膜外血肿的胸椎脊索瘤的罕见表现：1例罕见病例报告及PRISMA驱动的系统评价
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本文引用的文献

1
Chordoma: a systematic review of the epidemiology and clinical prognostic factors predicting progression-free and overall survival.脊索瘤：流行病学和临床预后因素的系统回顾，预测无进展生存期和总生存期。
Eur Spine J. 2018 Dec;27(12):3043-3058. doi: 10.1007/s00586-018-5764-0. Epub 2018 Sep 15.
2
Resection of a posterior mediastinal mass: Lessons learned from a failed exploration for presumed schwannoma.后纵隔肿物切除术：从假定的神经鞘瘤探查失败中吸取的教训
J Thorac Cardiovasc Surg. 2016 Oct;152(4):e75-7. doi: 10.1016/j.jtcvs.2016.04.030. Epub 2016 Apr 16.
3
Building a global consensus approach to chordoma: a position paper from the medical and patient community.
建立全球共识方法治疗 chordoma：来自医学和患者社区的立场文件。
Lancet Oncol. 2015 Feb;16(2):e71-83. doi: 10.1016/S1470-2045(14)71190-8.
4
Giant chordoma of the upper thoracic spine with mediastinal involvement: a surgical challenge.累及纵隔的上胸椎巨大脊索瘤：手术挑战
Asian Spine J. 2014 Jun;8(3):353-6. doi: 10.4184/asj.2014.8.3.353. Epub 2014 Jun 9.
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Giant mediastinal chordoma.巨大纵隔脊索瘤。
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Chondroid chordoma--a variant of chordoma. A morphologic and immunohistochemical study.软骨样脊索瘤——脊索瘤的一种变体。形态学与免疫组织化学研究。
Am J Clin Pathol. 1994 Jan;101(1):36-41. doi: 10.1093/ajcp/101.1.36.
7
Chordoma of the thorax.胸部脊索瘤
Eur J Respir Dis. 1986 Jan;68(1):68-72.