Bussel J B, Abboud M R
Crit Rev Oncol Hematol. 1987;7(1):37-51. doi: 10.1016/s1040-8428(87)80013-6.
Autoimmune neutropenia (AIN) of infancy is an underreported disease because of its benign nature. In addition, the relative unavailability of neutrophil antibody testing prevents confirmation of suspected diagnoses. Small children do not have life-threatening infections, do not have associated diseases, respond to i.v. gamma globulin with increased neutrophil counts, and tend to improve on their own. Older children with AIN have associated diseases such as hepatitis or Hodgkin's disease, often have other immune cytopenias, and respond poorly to any therapy. Immune deficiency states, especially those of the humoral arms, are associated with development of AIN.
婴儿期自身免疫性中性粒细胞减少症（AIN）因其良性性质而报告不足。此外，中性粒细胞抗体检测相对难以获得，这使得疑似诊断无法得到确认。幼儿不会发生危及生命的感染，没有相关疾病，静脉注射丙种球蛋白后中性粒细胞计数会增加，并且往往会自行好转。患有AIN的大龄儿童有诸如肝炎或霍奇金病等相关疾病，常常还有其他免疫性血细胞减少症，并且对任何治疗反应不佳。免疫缺陷状态，尤其是体液免疫方面的缺陷状态，与AIN的发生有关。
