机器人胃癌切除术与腹腔镜胃癌切除术肿瘤学结局的汇总分析
Pooled analysis of the oncological outcomes in robotic gastrectomy versus laparoscopic gastrectomy for gastric cancer.
作者信息
Wu Hong-Ying, Lin Xiu-Feng, Yang Ping, Li Wei
机构信息
Department of Geriatric Medicine II, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan Province, China.
Department of Gastrointestinal Surgery, Eastern Hospital, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan Province, China.
出版信息
J Minim Access Surg. 2021 Jul-Sep;17(3):287-293. doi: 10.4103/jmas.JMAS_69_20.
AIM
Robotic gastrectomy (RG) is more and more widely used in the treatment of gastric cancer. However, the long-term oncological outcomes of RG have not been well evaluated. The aim of this study was to evaluate the long-term oncological outcomes of RG and laparoscopic gastrectomy (LG) in the treatment of gastric cancer.
MATERIALS AND METHODS
PubMed, China National Knowledge Infrastructure, Cochrane Library and EMBASE electronic databases were searched until August 2019. Eligible studies were analysed for comparison of oncological outcomes between RG and LG in patients with gastric cancer.
RESULTS
Eleven retrospective comparative studies, which included 1347 (32.52%) patients in the RG group and 2795 (67.48%) patients in the LG group, were selected for the analysis. Meta-analysis of the 11 included studies showed that there was no statistically significant difference in the OS between the RG and LG groups (hazard ratios [HRs] = 0.97, 95% confidence intervals [CIs] = 0.80-1.19, P = 0.80). Six studies evaluated disease-free survival (DFS), and pooled analysis showed that there was no statistically significant difference in DFS between RG group and LG group (HR = 0.94, 95% CIs = 0.72-1.23, P = 0.65). According to the odds ratio (OR) analysis, there was no significant difference in 3-year OS, 5-year OS, 3-year DFS and 5-year DFS between the RG and LG groups. Nine articles reported the recurrence rate, and the meta-analysis showed that there was no statistically significant difference between the RG and LG groups (OR = 0.88, 95% CIs = 0.69-1.12, P = 0.31).
CONCLUSIONS
This meta-analysis indicated that the long-term oncological outcomes in the RG group were similar to that in the LG group.
目的
机器人胃癌切除术（RG）在胃癌治疗中的应用越来越广泛。然而，RG的长期肿瘤学结局尚未得到充分评估。本研究旨在评估RG和腹腔镜胃癌切除术（LG）治疗胃癌的长期肿瘤学结局。
材料与方法
检索PubMed、中国知网、考克兰图书馆和EMBASE电子数据库至2019年8月。对纳入的符合条件的研究进行分析，比较RG和LG治疗胃癌患者的肿瘤学结局。
结果
选择11项回顾性比较研究进行分析，其中RG组1347例（32.52%）患者，LG组2795例（67.48%）患者。对纳入的11项研究进行的荟萃分析显示，RG组和LG组的总生存期（OS）无统计学显著差异（风险比[HRs]=0.97，95%置信区间[CIs]=0.80-1.19，P=0.80）。6项研究评估了无病生存期（DFS），汇总分析显示RG组和LG组的DFS无统计学显著差异（HR=0.94，95% CIs=0.72-1.23，P=0.65）。根据比值比（OR）分析，RG组和LG组的3年总生存期、5年总生存期、3年无病生存期和5年无病生存期无显著差异。9篇文章报告了复发率，荟萃分析显示RG组和LG组之间无统计学显著差异（OR=0.88，95% CIs=0.69-1.12，P=0.31）。
结论
该荟萃分析表明，RG组的长期肿瘤学结局与LG组相似。
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