Brigham K L, Harris T R, Owen P J
J Appl Physiol Respir Environ Exerc Physiol. 1977 Jul;43(1):99-101. doi: 10.1152/jappl.1977.43.1.99.
To see whether, by avoiding red blood cell transport effects, [14C]-sucrose would be a more sensitive lung vascular permeability indicator than [14C]urea, we compared the effects of 4 microgram/kg-min intravenous histamine phosphate infusions on lung vascular permeability-surface area products (PS) for each indicator in the same unanesthetized sheep. Histamine caused hematocrit, PaCO2 and pHa to increase and pulmonary arterial pressure and Pa02 to decrease. [14C]Urea PS (integral extraction calculation) increased from a base line value of 14.7 +/- 1.5 SE ml/s to 17.7 +/- 1.3 (P less than 0.05) with histamine, but [14C]sucrose PS did not change (base line, 6.5 +/- 2.9; histamine, 5.8 +/- 1.2). We conclude that [14C]urea is probably a more useful permeability indicator in the lung circulation than [14C]sucrose, because urea is more sensitive to moderate increases in permeability.
为了探究通过避免红细胞转运效应，[14C] - 蔗糖是否会成为比[14C]尿素更敏感的肺血管通透性指标，我们在同一未麻醉的绵羊中比较了以4微克/千克·分钟的速度静脉输注磷酸组胺对每种指标的肺血管通透性 - 表面积乘积（PS）的影响。组胺导致血细胞比容、动脉血二氧化碳分压（PaCO2）和动脉血pH值升高，肺动脉压和动脉血氧分压（PaO2）降低。[14C]尿素的PS（积分提取计算）在输注组胺后从基线值14.7±1.5 SE毫升/秒增加到17.7±1.3（P<0.05），但[14C]蔗糖的PS没有变化（基线值为6.5±2.9；组胺作用后为5.8±1.2）。我们得出结论，在肺循环中，[14C]尿素可能是比[14C]蔗糖更有用的通透性指标，因为尿素对通透性的适度增加更敏感。
