Atiea J A, Ryder R R, Vora J, Owens D R, Luzio S D, Williams S, Hayes T M
Diabetes Care. 1987 Jul-Aug;10(4):461-5. doi: 10.2337/diacare.10.4.461.
The frequency of the dawn phenomenon has been studied in non-insulin-dependent diabetic (NIDDM) patients while they continued with their conventional therapy. Plasma glucose (PG) and immunoreactive insulin (IRI) were estimated hourly from 0300 to 0900 h in 19 NIDDM patients; 9 patients were treated by diet alone (group 1), and 10 patients were treated by diet and oral hypoglycemic agents (group 2). The dawn rise of plasma glucose was demonstrated in 17 (89.5%) of the 19 patients with mean +/- SE plasma glucose at 0300 h of 7.0 +/- 0.5 mM and at 0800 h of 8.4 +/- 0.6 (P less than .01). IRI in all patients rose from 14.7 +/- 1.3 microU/ml at 0500 h to 18.1 +/- 1.8 microU/ml at 0700 h (P less than .05). The changes in IRI levels at any time from 0300 to 0800 h in groups 1 and 2 when considered separately were insignificant. Thus, the dawn phenomenon occurs commonly in NIDDM patients taking their conventional therapy.
在非胰岛素依赖型糖尿病（NIDDM）患者继续接受常规治疗期间，对黎明现象的发生率进行了研究。对19例NIDDM患者在03:00至09:00每小时测定一次血浆葡萄糖（PG）和免疫反应性胰岛素（IRI）；9例患者仅接受饮食治疗（第1组），10例患者接受饮食和口服降糖药治疗（第2组）。19例患者中有17例（89.5%）出现了血浆葡萄糖的黎明升高，03:00时血浆葡萄糖均值±标准误为7.0±0.5 mM，08:00时为8.4±0.6（P<0.01）。所有患者的IRI从05:00时的14.7±1.3微单位/毫升升至07:00时的18.1±1.8微单位/毫升（P<0.05）。分别考虑时，第1组和第2组在03:00至08:00任何时间的IRI水平变化均无统计学意义。因此，黎明现象在接受常规治疗的NIDDM患者中普遍存在。
