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采用改良的呼吸器适配性测试设备来测量医疗和消费材料的过滤效率。

Measurement of filtration efficiencies of healthcare and consumer materials using modified respirator fit tester setup.

机构信息

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.

University of Illinois College of Medicine at Urbana, Urbana, Illinois, United States of America.

出版信息

PLoS One. 2020 Oct 13;15(10):e0240499. doi: 10.1371/journal.pone.0240499. eCollection 2020.

Abstract

During the current SARS-CoV-2 pandemic there is unprecedented demand for personal protective equipment (PPE), especially N95 respirators and surgical masks. The ability of SARS-CoV-2 to be transmitted via respiratory droplets from asymptomatic individuals has necessitated increased usage of both N95 respirators in the healthcare setting and masks (both surgical and homemade) in public spaces. These precautions rely on two fundamental principles of transmission prevention: particle filtration and droplet containment. The former is the focus of NIOSH N95 testing guidelines, and the latter is an FDA guideline for respirators and surgical masks. While studies have investigated droplet containment to provide guidance for homemade mask production, limited work has been done to characterize the filtration efficiency (FE) of materials used in home mask making. In this work, we demonstrate the low-cost (<$300) conversion of standard equipment used to fit-test respirators in hospital and industrial settings into a setup that measures quantitative FEs of materials based on NIOSH N95 guidelines, and subsequently measure FEs of materials found in healthcare and consumer spaces. These materials demonstrate significant variability in filtration characteristics, even for visually similar materials. We demonstrate a FE of 96.49% and pressure drop of 25.4 mmH20 for a double-layer of sterilization wrap used in surgical suites and a FE of 90.37% for a combination of consumer-grade materials. The excellent filtration characteristics of the former demonstrate potential utility for emergent situations when N95 respirators are not available, while those of the latter demonstrate that a high FE can be achieved using publicly available materials.

摘要

在当前的 SARS-CoV-2 大流行期间,对个人防护设备(PPE)的需求空前,特别是 N95 呼吸器和手术口罩。SARS-CoV-2 能够通过无症状个体的呼吸道飞沫传播,这使得医疗环境中 N95 呼吸器和口罩(包括手术口罩和自制口罩)的使用量增加。这些预防措施依赖于两个预防传播的基本原则:颗粒过滤和飞沫遏制。前者是 NIOSH N95 测试指南的重点,后者是 FDA 对呼吸器和手术口罩的指南。虽然已经有研究调查了飞沫遏制以提供自制口罩生产的指导,但对家用口罩生产中使用的材料的过滤效率(FE)进行特征描述的工作却很少。在这项工作中,我们展示了将用于在医院和工业环境中 fit-test 呼吸器的标准设备低成本(<$300)转换为一种基于 NIOSH N95 指南测量材料定量 FE 的设备,并随后测量医疗和消费环境中发现的材料的 FE。这些材料的过滤特性存在显著差异,即使是外观相似的材料也是如此。我们展示了两层消毒包装材料的过滤效率为 96.49%,压降为 25.4mmH20,这些材料用于手术套件;以及由消费者级材料组成的组合的过滤效率为 90.37%。前者具有出色的过滤特性,当 N95 呼吸器无法使用时,具有潜在的实用价值,而后者表明可以使用公开可用的材料实现高 FE。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0320/7553287/ed5cd035c87c/pone.0240499.g001.jpg

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