The polymorphic inheritance of rs225014 may predict body weight variation after Graves' disease treatment.

OBJECTIVE

We aimed to investigate the role of polymorphisms rs225014 and rs12885300 in Graves' disease patients, mainly for controlling body weight following treatment.

METHODS

We genotyped 280 GD patients by the time of diagnosis and 297 healthy control individuals using a TaqMan SNP Genotyping technique. We followed up 141 patients for 18.94 ± 6.59 months after treatment.

RESULTS

There was no relationship between the investigated polymorphisms with susceptibility to GD and gain or loss of weight after GD treatment. However, the polymorphic inheritance (CC+CT genotype) of rs225014 was associated with a lower body weight variation after GD treatment (4.26 ± 6.25 kg) when compared to wild type TT genotype (6.34 ± 7.26 kg; p = 0.0456 adjusted for the follow-up time). This data was confirmed by a multivariate analysis (p = 0.0138) along with a longer follow-up period (p = 0.0228), older age (p = 0.0306), treatment with radioiodine (p-value = 0.0080) and polymorphic inheritance of rs12885300 (p = 0.0306).

CONCLUSION

We suggest that rs225014 genotyping may have an auxiliary role in predicting the post-treatment weight behavior of GD patients.