Olofinnade Anthony Tope, Onaolapo Adejoke Yeunde, Onaolapo Olakunle James, Olowe Olugenga Adekunle, Mollica Adriano, Zengin Gokhan, Stefanucci Azurra
Lagos State University, Ikeja, Lagos State.
Ladoke Akintola University of Technology, P.M.B 4000, Oyo state, Nigeria.
Front Biosci (Landmark Ed). 2021 Jan 1;26(3):537-551. doi: 10.2741/4906.
Consumption of a high-fat diet has adverse impacts on metabolism, neurobehavioral, and neurochemical homeostasis in both humans and experimental animals. Here, we examined the effects of two different cultivars of Corylus avellana L. in a mouse model of metabolic syndrome. Corylus avellana L. reduced weight gain in mice that were treated with a high-fat diet, improved their behavioral parameters as exemplified by locomotion and rearing, working-memory, and reduced grooming and anxiety indices. Both Corylus avellana L. varieties reduced blood glucose levels and lipid peroxidation, improved lipid profile, and antioxidant status in mice placed on a high fat diet. Finally, brain acetylcholinesterase activity was also reduced, dopamine level was increased, while caspase-3 level in the brain was reduced. Thus, the Corylus avellana L. cultivars improve metabolic, behavioral, and neurochemical homeostasis in a diet with a high-fat content.
食用高脂肪饮食对人类和实验动物的新陈代谢、神经行为及神经化学稳态均有不利影响。在此，我们在代谢综合征小鼠模型中研究了两种不同品种的欧洲榛子的作用。欧洲榛子可减少高脂饮食小鼠的体重增加，改善其行为参数，如运动和竖毛行为、工作记忆，并降低梳理和焦虑指数。两种欧洲榛子品种均可降低高脂饮食小鼠的血糖水平和脂质过氧化，改善血脂状况和抗氧化状态。最后，脑乙酰胆碱酯酶活性也降低，多巴胺水平升高，而脑中半胱天冬酶-3水平降低。因此，欧洲榛子品种可改善高脂饮食中的代谢、行为及神经化学稳态。
